NUDT4 cdna clone
NUDT4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]
Uniprot Description
NUDT4: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Belongs to the Nudix hydrolase family. DIPP subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.1.52; Hydrolase
Chromosomal Location of Human Ortholog: 12q21
Cellular Component: cytosol; intracellular
Molecular Function: diphosphoinositol-polyphosphate diphosphatase activity; m7G(5')pppN diphosphatase activity; protein binding; snoRNA binding
Biological Process: calcium-mediated signaling; cyclic nucleotide metabolic process; cyclic-nucleotide-mediated signaling; inositol phosphate metabolic process; intracellular transport; regulation of RNA export from nucleus
Research Articles on NUDT4
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Product Notes
The NUDT4 nudt4 (Catalog #AAA1268154) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgatgaagt tcaagcccaa ccagacgcgg acctacgacc gcgagggctt caagaagcgg gcggcgtgcc tgtgcttccg gagcgagcag gaggacgagg tgctgctggt gagtagcagc cggtacccag accagtggat tgtcccagga ggaggaatgg aacccgagga ggaacctggc ggtgctgccg tgagggaagt ttatgaggag gctggagtca aaggaaaact aggcagactt ctgggcatat ttgagaacca agaccgaaag cacagaacat atgtttatgt tctaacagtc actgaaatat tagaagattg ggaagattct gttaatattg gaaggaagag agagtggttc aaagtagaag atgctatcaa agttctccag tgtcataaac ctgtacatgc agagtatctg gaaaagctaa agctgggttg ttccccagcc aatggaaatt ctacagtccc ttcccttccg gataataatg ccttgtttgt aaccgctgca cagacctctg ggttgccatc tagtgtaaga tag. It is sometimes possible for the material contained within the vial of "NUDT4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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