NUDT14 cdna clone

NUDT14

Cat. Num. AAA200933

• Gene Names: NUDT14; UGPP; UGPPase
• Synonyms: NUDT14; UGPP; UGPPase; NUDT14 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGGAGCGCATCGAGGGGGCGTCCGTGGGCCGCTGCGCCGCCTCACCCTACCTGCGGCCGCTCACGCTGCATTACCGCCAGAATGGTGCCCAGAAGTCCTGGGACTTCATGAAGACGCATGACAGCGTGACCGTTCTCTTATTCAACTCTTCTCGGAGGAGCCTGGTGTTGGTGAAGCAGTTCCGGCCAGCTGTGTATGCGGGTGAGGTGGAGCGCCGCTTCCCAGGGTCCCTAGCAGCTGTAGACCAGGACGGGCCTCGGGAGCTACAGCCAGCCCTGCCCGGCTCAGCGGGGGTGACAGTTGAGCTGTGTGCCGGCCTCGTGGACCAGCCTGGGCTCTCGCTGGAGGAAGTGGCTTGCAAGGAGGCTTGGGAGGAGTGTGGCTACCACTTGGCCCCCTCTGATCTGCGCCGGGTCGCCACATACTGGTCTGGAGTGGGACTGACTGGCTCCAGACAGACCATGTTCTACACAGAGGTGACAGATGCCCAGCGTAGCGGTCCAGGTGGGGGCCTGGTGGAGGAGGGTGAGCTCATTGAGGTGGTGCACCTGCCCCTGGAAGGCGCCCAGGCCTTTGCAGACGACCCGGACATCCCCAAGACCCTCGGCGTCATCTTTGGTGTCTCATGGTTCCTCAGCCAGGTGGCCCCCAACCTGGATCTCCAGTGA; ; Translation Sequence: MERIEGASVG RCAASPYLRP LTLHYRQNGA QKSWDFMKTH DSVTVLLFNS SRRSLVLVKQ FRPAVYAGEV ERRFPGSLAA VDQDGPRELQ PALPGSAGVT VELCAGLVDQ PGLSLEEVAC KEAWEECGYH LAPSDLRRVA TYWSGVGLTG SRQTMFYTEV TDAQRSGPGG GLVEEGELIE VVHLPLEGAQ AFADDPDIPK TLGVIFGVSW FLSQVAPNLD LQ
• Sequence Length: 222

• Species: Human
• Chromosome Location: 14q32.33
• OMIM Reference Number: 609219
• cDNA Size: 669bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for NUDT14 cdna clone

NUDT14 is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. UDP-glucose (UDPG) acts as the sugar donor in numerous glycosylation reactions, including those involved in the production of glycogen.

Product Categories/Family for NUDT14 cdna clone

Metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 37594467
• NCBI GeneID: 256281
• NCBI Accession #: NP_803877.2
• NCBI GenBank Nucleotide #: NM_177533.3
• UniProt Accession #: O95848
• NCBI Official Full Name: uridine diphosphate glucose pyrophosphatase NUDT14 isoform 1
• NCBI Official Synonym Full Names: nudix hydrolase 14
• NCBI Official Symbol: NUDT14
• NCBI Official Synonym Symbols: UGPP; UGPPase
• NCBI Protein Information: uridine diphosphate glucose pyrophosphatase NUDT14
• UniProt Protein Name: Uridine diphosphate glucose pyrophosphatase
• Protein Family: Nudix hydrolase
• UniProt Gene Name: NUDT14
• UniProt Synonym Gene Names: UGPP; UDPG pyrophosphatase; UGPPase; Nudix motif 14
• UniProt Entry Name: NUD14_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

NUDT14: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose. Belongs to the Nudix hydrolase family.

Protein type: EC 3.6.1.45; Hydrolase

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: cytoplasm

Molecular Function: protein binding; ADP-ribose diphosphatase activity; metal ion binding; UDP-sugar diphosphatase activity

Biological Process: metabolic process