NUDT1 cdna clone
NUDT1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
Uniprot Description
NUDT1: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Belongs to the Nudix hydrolase family. 4 isoforms of the human protein are produced by alternative initiation.
Protein type: EC 3.6.1.56; EC 3.6.1.55; Hydrolase
Chromosomal Location of Human Ortholog: 7p22
Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion; nucleus
Molecular Function: 8-oxo-7,8-dihydroguanine triphosphatase activity; ATP diphosphatase activity; GTPase activity; m7G(5')pppN diphosphatase activity; protein binding; snoRNA binding
Biological Process: dATP catabolic process; dGTP catabolic process; DNA protection; DNA repair; purine nucleotide catabolic process; response to oxidative stress
Research Articles on NUDT1
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Product Notes
The NUDT1 nudt1 (Catalog #AAA1274051) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGGCGCCT CCAGGCTCTA TACCCTGGTG CTGGTCCTGC AGCCTCAGCG AGTTCTCCTG GGCATGAAAA AGCGAGGCTT CGGGGCCGGC CGGTGGAATG GCTTTGGGGG CAAAGTGCAA GAAGGAGAGA CCATCGAGGA TGGGGCTAGG AGGGAGCTGC AGGAGGAGAG CGGTCTGACA GTGGACGCCC TGCACAAGGT GGGCCAGATC GTGTTTGAGT TCGTGGGCGA GCCTGAGCTC ATGGACGTGC ATGTCTTCTG CACAGACAGC ATCCAGGGGA CCCCCGTGGA GAGCGACGAA ATGCGCCCAT GCTGGTTCCA GCTGGATCAG ATCCCCTTCA AGGACATGTG GCCCGACGAC AGCTACTGGT TTCCACTCCT GCTTCAGAAG AAGAAATTCC ACGGGTACTT CAAGTTCCAG GGTCAGGACA CCATCCTGGA CTACACACTC CGCGAGGTGG ACACGGTCTA G. It is sometimes possible for the material contained within the vial of "NUDT1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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