NR4A2 cdna clone
NR4A2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 2q22-q23
Cellular Component: nucleoplasm; nucleus
Molecular Function: beta-catenin binding; DNA binding; ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; retinoid X receptor binding
Biological Process: cellular response to extracellular stimulus; fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin
Disease: Parkinson Disease, Late-onset
Research Articles on NR4A2
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Product Notes
The NR4A2 nr4a2 (Catalog #AAA1276955) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgccttgtg ttcaggcgca gtatgggtcc tcgcctcaag gagccagccc cgcttctcag agctacagtt accactcttc gggagaatac agctccgatt tcttaactcc agagtttgtc aagtttagca tggacctcac caacactgaa atcactgcca ccacttctct ccccagcttc agtaccttta tggacaacta cagcacaggc tacgacgtca agccaccttg cttgtaccaa atgcccctgt ccggacagca gtcctccatt aaggtagaag acattcagat gcacaactac cagcaacaca gccacctgcc cccccagtct gaggagatga tgccgcactc cgggtcggtt tactacaagc cctcctcgcc cccgacgccc accaccccgg gcttccaggt gcagcacagc cccatgtggg acgacccggg atctctccac aacttccacc agaactacgt ggccactacg cacatgatcg agcagaggaa aacgccagtc tcccgcctct ccctcttctc ctttaagcaa tcgccccctg gcaccccggt gtctagttgc cagatgcgct tcgacgggcc cctgcacgtc cccatgaacc cggagcccgc cggcagccac cacgtggtgg acgggcagac cttcgctgtg cccaacccca ttcgcaagcc cgcgtccatg ggcttcccgg gcctgcagat cggccacgcg tctcagctgc tcgacacgca ggtgccctca ccgccgtcgc ggggctcccc ctccaacgag gggctgtgcg ctgtgtgtgg ggacaacgcg gcctgccaac actacggcgt gcgcacctgt gagggctgca aaggcttctt taagcgcaca gtgcaaaaaa atgcaaaata cgtgtgttta gcaaataaaa actgcccagt ggacaagcgt cgccggaatc gctgtcagta ctgccgattt cagaagtgcc tggctgttgg gatggtcaaa gaagtggttc gcacagacag tttaaaaggc cggagaggtc gtttgccctc gaaaccgaag agcccacagg agccctctcc cccttcgccc ccggtgagtc tgatcagtgc cctcgtcagg gcccatgtcg actccaaccc ggctatgacc agcctggact attccaggtt ccaggcgaac cctgactatc aaatgagtgg agatgacacc cagcatatcc agcaattcta tgatctcctg actggctcca tggagatcat ccggggctgg gcagagaaga tccctggctt cgcagacctg cccaaagccg accaagacct gctttttgaa tcagctttct tagaactgtt tgtccttcga ttagcataca ggtccaaccc agtggagggt aaactcatct tttgcaatgg ggtggtcttg cacaggttgc aatgcgttcg tggctttggg gaatggattg attccattgt tgaattctcc tccaacttgc agaatatgaa catcgacatt tctgccttct cctgcattgc tgccctggct atggtcacag agagacacgg gctcaaggaa cccaagagag tggaagaact gcaaaacaag attgtaaatt gtctcaaaga ccacgtgact ttcaacaatg gggggttgaa ccgccccaat tatttgtcca aactgttggg gaagctccca gaacttcgta ccctttgcac acaggggcta cagcgcattt tctacctgaa attggaagac ttggtgccac cgccagcaat aattgacaaa cttttcctgg acactttacc tttctaa. It is sometimes possible for the material contained within the vial of "NR4A2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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