NARF cdna clone
NARF cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
Uniprot Description
NARF: Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: lamin filament; nuclear lamina; nuclear lumen
Molecular Function: lamin binding
Research Articles on NARF
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Product Notes
The NARF narf (Catalog #AAA1277179) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagtgtg agcactgcac gcgcaaggaa tgtagtaaga aaacaaaaac tgatgaccaa gagaatgtgt cagccgatgc accgagtcca gcccaggaaa atggagagaa gggagaattc cacaagttgg ctgatgccaa gatatttttg agcgactgcc tggcatgtga cagctgtatg actgcagagg aaggagtcca actttcccag caaaatgcca aggacttctt ccgcgttctg aaccttaaca agaaatgtga tacctcaaag cacaaagtgc tggtagtgtc tgtgtgtcct caatctttgc cttattttgc tgctaaattc aacctcagtg taactgatgc atccagaaga ctctgtggtt tcctcaaaag tcttggggtg cactatgtat ttgatacgac gatagctgcg gattttagta tcctggagag tcaaaaagaa ttcgtgcgtc gctatcgcca gcacagtgag gaggaacgca ccctgcccat gctgacctct gcctgtcctg gctgggtccg atacgccgag cgggtgctgg gtcgccccat cactgcccac ctctgcaccg ccaagtcccc ccagcaggtc atgggctctt tggtgaagga ttatttcgcc agacagcaga acctgtctcc agagaagatt ttccacgtca ttgtggcccc ttgttatgac aagaagctgg aggctcttca ggaaagcctt ccccctgctt tgcatggctc ccggggcgct gactgcgtgt taacatcaga aattagccag gcgtggtggt gcacacctgt gatcacagct actcgggagg ctgcggcaag agaatcactt gaacccggga ggcagaggtt acagcgagac aagattgcac cactggactc cagcctgggc ggcggaggtg aaattgctca aataatggag caaggtgacc tctcagtgag agatgctgcc gtcgacactc tgtttggaga cttgaaggag gacaaagtga cgcgtcatga tggagccagc tcagacgggc acctggcaca catcttcaga catgcggcca aggagctgtt caacgaggat gtggaggagg tcacttaccg agccctgaga aacaaagact tccaagaggt cacccttgag aagaacggag aggtggtgtt acgctttgct gcagcctatg gctttcgaaa catccagaac atgatcctga agcttaagaa gggcaagttc ccattccact ttgtggaggt cctcgcctgt gctggaggat gcttaaatgg cagaggccaa gcccagactc cagacggaca tgcggataag gccctgctgc ggcagatgga aggcatttac gctgacatcc ctgtgcggcg tccggagtcc agtgcacacg tgcaggagct gtaccaggag tggctggagg ggatcaactc ccccaaggcc cgagaggtgc tgcataccac gtaccagagc caggagcgtg gcacacacag cctggacatc aagtggtga. It is sometimes possible for the material contained within the vial of "NARF, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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