MLH3 cdna clone
MLH3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
MLH3: Probably involved in the repair of mismatches in DNA. Defects in MLH3 are the cause of hereditary non-polyposis colorectal cancer type 7 (HNPCC7). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. Defects in MLH3 are a cause of colorectal cancer (CRC). Belongs to the DNA mismatch repair MutL/HexB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage; Cell cycle regulation
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: chiasma; nucleus; synaptonemal complex
Molecular Function: ATPase activity; protein binding; satellite DNA binding; single-stranded DNA binding
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 7; Endometrial Cancer
Research Articles on MLH3
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Product Notes
The MLH3 mlh3 (Catalog #AAA1277962) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgatcaagt gcttgtcagt tgaagtacaa gccaaattgc gttctggttt ggccataagc tccttgggcc aatgtgttga ggaacttgcc ctcaacagta ttgatgctga agcaaaatgt gtggctgtca gggtgaatat ggaaaccttc caagttcaag tgatagacaa tggatttggg atggggagtg atgatgtaga gaaagtggga aatcgttatt tcaccagtaa atgccactcg gtacaggact tggagaatcc aaggttttat ggtttccgag gagaggcctt ggcaaatatt gctgacatgg ccagtgctgt ggaaatttcg tccaagaaaa acaggacaat gaaaactttt gtgaaactgt ttcagagtgg aaaagccctg aaagcttgtg aagctgatgt gactagagca agcgctggga ctactgtaac agtgtataac ctattttacc agcttcctgt aaggaggaaa tgcatggacc ctagactgga gtttgagaag gttaggcaga gaatagaagc tctctcactc atgcaccctt ccatttcttt ctctttgaga aatgatgttt ctggttccat ggttcttcag ctccctaaaa ccaaagacgt atgttcccga ttttgtcaaa tttatggatt gggaaagtcc caaaagctaa gagaaataag ttttaaatat aaagagtttg agcttagtgg ctatatcagc tctgaagcac attacaacaa gaatatgcag tttttgtttg tgaacaaaag actagtttta aggacaaagc tacataaact cattgacttt ttattaagga aagaaagtat tatatgcaag ccaaagaatg gtcccaccag taggcaaatg aattcaagtc ttcggcaccg gtctacccca gaactctatg gcatatatgt aattaatgtg cagtgccaat tctgtgagta tgatgtgtgc atggagccag ccaaaactct gattgaattt cagaactggg acactctctt gttttgcatt caggaaggag tgaaaatgtt tttaaagcaa gaaaaattat ttgtggaatt atcaggtgag gatattaagg aatttagtga agataatggt tttagtttat ttgatgctac tcttcagaag cgtgtgactt ccgatgagag gagcaatttc caggaagcat gtaataatat tttagattcc tatgagatgt ttaatttgca gtcaaaagct gtgaaaagaa aaactactgc agaaaacgta aacacacaga gttctaggga ttcagaagct accagaaaaa atacaaatga tgcatttttg tacatttatg aatcaggtgg tccaggccat agcaaaatga cagagccatc tttacaaaac aaagacagct cttgctcaga atcaaagatg ttagaacaag agacaattgt agcatcagaa gctggagaaa atgagaaaca taaaaaatct ttcctggaac atagctcttt agaaaatccg tgtggaacca gtttagaaat gtttttaagc ccttttcaga caccatgtca ctttgaggag agtgggcagg atctagaaat atggaaagaa agtactactg ttaatggcat ggctgccaac atcttgaaaa ataatagaat tcagaatcaa ccaaagagat ttaaagatgc tactgaagtg ggatgccagc ctctgccttt tgcaacaaca ttatggggag tacatagtgc tcagacagag aaagagaaaa aaaaagaatc tagcaattgt ggaagaagaa atgtttttag ttatgggcga gttaaattat gttccactgg ctttataact catgtagtac aaaatgaaaa aactaaatca actgaaacag aacattcatt taaaaattat gttagacctg gtcccacacg tgcccaagaa acatttggaa atagaacacg tcattcagtt gaaactccag acatcaaaga tttagccagc actttaagta aagaatctgg tcaattgccc aacaaaaaaa attgcagaac gaatataagt tatgggctag agaatgaacc tacagcaact tatacaatgt tttctgcttt tcaggaaggt agcaaaaaat cacaaacaga ttgcatatta tctgatacat ccccctcttt cccctggtat agacacgttt ccaatgatag taggaaaaca gataaattaa ttggtttctc caaaccaatc gtccgtaaga agctaagctt gagttcacag ctaggatctt tagagaagtt taagaggcaa tatgggaagg ttgaaaatcc tctggataca gaagtagagg aaagtaatgg agtcactacc aatctcagtc ttcaagttga acctgacatt ctgctgaagg acaagaaccg cttagagaac tctgatgttt gtaaaatcac tactatggag catagtgatt cagatagtag ttgtcaacca gcaagccaca tccttgactc agagaagttt ccattctcca aggatgaaga ttgtttagaa caacagatgc ttagtttgag agaaagtcct atgaccctga aggagttatc tctctttaat agaaaacctt tggaccttga gaagtcatct gaatcactag cctctaaatt atccagactg aagggttccg aaagagaaac tcaaacaatg gggatgatga gtcgttttaa tgaacttcca aattcagatt ccagtaggaa agacagcaag ttgtgcagtg tgttaacaca agatttttgt atgttattta acaacaagca tgaaaaaaca gagaatggtg tcatcccaac atcagattct gccacacagg ataattcctt taataaaaat agtaaaacac attctaacag caatacaaca gagaactgtg tgatatcaga aactcctttg gtattgccct ataataattc taaagttacc ggtaaagatt cagatgttct tatcagagcc tcagaacaac agataggaag tcttgactct cccagtggaa tgttaatgaa tccggtagaa gatgccacag gtgaccaaaa tggaatttgt tttcagagtg aggaatctaa agcaagagct tgttctgaaa ctgaagagtc aaacacgtgt tgttcagatt ggcagcggca tttcgatgta gccctgggaa gaatggttta tgtcaacaaa atgactggac tcagcacatt cattgcccca actgaggaca ttcaggctgc ttgtactaaa gacctgacaa ctgtggctgt ggatgttgta cttgagaatg ggtctcagta caggtgtcaa ccttttagaa gcgaccttgt tcttcctttc cttccgagag ctcgagcaga gaggactgtg atgagacagg ataacagaga tactgtggat gatactgtta gtagcgaatc gcttcagtct ttgttctcag aatgggacaa tccagtattt gcccgttatc cagaggttgc tgttgatgta agcagtggcc aggctgagag cttagcagtt aaaattcaca acatcttgta tccctatcgt ttcaccaaag gaatgattca ttcaatgcag gttctccagc aagtagataa caagtttatt gcctgtttga tgagcactaa gactgaagag aatggcgagg cagattccta cgagaagcaa caggcacaag gctctggtcg gaaaaaatta ctgtcttcta ctctaattcc tccgctagag ataacagtga cagaggaaca aaggagactc ttatggtgtt accacaaaaa tctggaagat ctgggccttg aatttgtatt tccagacact agtgattctc tggtccttgt gggaaaagta ccactatgtt ttgtggaaag agaagccaat gaacttcgga gaggaagatc tactgtgacc aagagtattg tggaggaatt tatccgagaa caactggagc tactccagac caccggaggc atccaaggga cattgccact gactgtccag aaggtgttgg catcccaagc ctgccatggg gccattaagt ttaatgatgg cctgagctta caggaaagtt gccgccttat tgaagctctg tcctcatgcc agctgccatt ccagtgtgct cacgggagac cttctatgct gccgttagct gacatagacc acttggaaca ggaaaaacag attaaaccca acctcactaa acttcgcaaa atggcccagg cctggcgtct ctttggaaaa gcagagtgtg atacaaggca gagcctgcag caatccatgc ctccctgtga gccaccatga. It is sometimes possible for the material contained within the vial of "MLH3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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