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Western Blot (WB) (Western blot analysis of extracts from K562 cells and HT-29 cells, using MLH3 antibody.)

anti-Human MLH3 Antibody | anti-MLH3 antibody

MLH3 Antibody

Gene Names
MLH3; HNPCC7
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
MLH3; MLH3 Antibody; DNA mismatch repair protein Mlh3; MutL protein homolog 3; anti-MLH3 antibody
Ordering
For Research Use Only!
Reactivity
Human
Specificity
MLH3 antibody detects endogenous levels of total MLH3 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
1453
Applicable Applications for anti-MLH3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:500~1:1000
ELISA: 1:40000
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human MLH3.
Preparation and Storage
Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from K562 cells and HT-29 cells, using MLH3 antibody.)

Western Blot (WB) (Western blot analysis of extracts from K562 cells and HT-29 cells, using MLH3 antibody.)
References
Lipkin S.M., Nat. Genet. 24:27-35(2000). Kondo E., Nucleic Acids Res. 29:1695-1702(2001). Lipkin S.M., Hum. Mutat. 17:389-396(2001).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
161,021 Da
NCBI Official Full Name
DNA mismatch repair protein Mlh3 isoform 1
NCBI Official Synonym Full Names
mutL homolog 3
NCBI Official Symbol
MLH3
NCBI Official Synonym Symbols
HNPCC7
NCBI Protein Information
DNA mismatch repair protein Mlh3
UniProt Protein Name
DNA mismatch repair protein Mlh3
UniProt Gene Name
MLH3

NCBI Description

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Probably involved in the repair of mismatches in DNA.

Research Articles on MLH3

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Product Notes

The MLH3 mlh3 (Catalog #AAA851241) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The MLH3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MLH3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500~1:1000 ELISA: 1:40000. Researchers should empirically determine the suitability of the MLH3 mlh3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MLH3, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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