MDH1 cdna clone
MDH1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
Uniprot Description
MDH1: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Protein type: Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - citrate (TCA) cycle; Oxidoreductase; EC 1.1.1.37; EC 1.1.1.96
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: centrosome; cytoplasm; cytosol; extracellular space
Molecular Function: L-malate dehydrogenase activity; malic enzyme activity; protein binding
Biological Process: gluconeogenesis; positive regulation of defense response to virus by host
Research Articles on MDH1
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Product Notes
The MDH1 mdh1 (Catalog #AAA1266047) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctgaac caatcagagt ccttgtgact ggagcagctg gtcaaattgc atattcactg ctgtacagta ttggaaatgg atctgtcttt ggtaaagatc agcctataat tcttgtgctg ttggatatca cccccatgat gggtgtcctg gacggtgtcc taatggaact gcaagactgt gcccttcccc tcctgaaaga tgtcatcgca acagataaag aagacgttgc cttcaaagac ctggatgtgg ccattcttgt gggctccatg ccaagaaggg aaggcatgga gagaaaagat ttactgaaag caaatgtgaa aatcttcaaa tcccagggtg cagccttaga taaatacgcc aagaagtcag ttaaggttat tgttgtgggt aatccagcca ataccaactg cctgactgct tccaagtcag ctccatccat ccccaaggag aacttcagtt gcttgactcg tttggatcac aaccgagcta aagctcaaat tgctcttaaa cttggtgtga ctgctaatga tgtaaagaat gtcattatct ggggaaacca ttcctcgact cagtatccag atgtcaacca tgccaaggtg aaattgcaag gaaaggaagt tggtgtttat gaagctctga aagatgacag ctggctcaag ggagaatttg tcacgactgt gcagcagcgt ggcgctgctg tcatcaaggc tcgaaaacta tccagtgcca tgtctgctgc aaaagccatc tgtgaccacg tcagggacat ctggtttgga accccagagg gagagtttgt gtccatgggt gttatctctg atggcaactc ctatggtgtt cctgatgatc tgctctactc attccctgtt gtaatcaaga ataagacctg gaagtttgtt gaaggtctcc ctattaatga tttctcacgt gagaagatgg atcttactgc aaaggaactg acagaagaaa aagaaagtgc ttttgaattt ctttcctctg cctga. It is sometimes possible for the material contained within the vial of "MDH1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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