Western Blot (WB)
(LIG3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the LIG3 antibody detected the LIG3 protein (arrow).)
Rabbit LIG3 Polyclonal Antibody | anti-LIG3 antibody
LIG3 Antibody (C-term)
Western Blot (WB)
(LIG3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the LIG3 antibody detected the LIG3 protein (arrow).)
Western Blot (WB)
(LIG3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the LIG3 antibody detected the LIG3 protein (arrow).)
member of this family encodes a protein that catalyzes the joining
of DNA ends but they each have a distinct role in DNA metabolism.
The protein encoded by this gene is involved in excision repair and
is located in both the mitochondria and nucleus, with translation
initiation from the upstream start codon allowing for transport to
the mitochondria and translation initiation from a downstream start
codon allowing for transport to the nucleus. Additionally,
alternate transcriptional splice variants, encoding different
isoforms, have been characterized.
Arora, M., et al. Leukemia 24(8):1470-1475(2010)
Cotner-Gohara, E., et al. Biochemistry 49(29):6165-6176(2010)
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
LIG3: Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Belongs to the ATP-dependent DNA ligase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; EC 6.5.1.1
Chromosomal Location of Human Ortholog: 17q11.2-q12
Cellular Component: nucleoplasm; mitochondrion; chromosome; synaptonemal complex; nucleus
Molecular Function: protein binding; DNA binding; DNA ligase activity; zinc ion binding; DNA ligase (ATP) activity; ATP binding
Biological Process: mitochondrial DNA repair; mitochondrion organization and biogenesis; negative regulation of DNA recombination; V(D)J recombination; base-excision repair, DNA ligation; DNA repair; cell cycle; lagging strand elongation; double-strand break repair via nonhomologous end joining; DNA ligation; nucleotide-excision repair; cell division; base-excision repair; double-strand break repair
Research Articles on LIG3
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Product Notes
The LIG3 lig3 (Catalog #AAA9213666) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 793-822. The LIG3 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's LIG3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the LIG3 lig3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LIG3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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