MCM8 cdna clone
MCM8 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
Uniprot Description
MCM8: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. Belongs to the MCM family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; EC 3.6.4.12
Chromosomal Location of Human Ortholog: 20p12.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: DNA replication; female gamete generation; G1/S transition of mitotic cell cycle; male gamete generation; response to DNA damage stimulus
Disease: Premature Ovarian Failure 10
Research Articles on MCM8
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Product Notes
The MCM8 mcm8 (Catalog #AAA1267018) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcttttc tttgtgctgc atgtggagaa attcagagct ttcctcttcc agatggaaaa tacagtcttc ccacaaagtg tcctgtgcct gtgtgtcgag gcaggtcatt tactgctctc cgcagctctc ctctcacagt tacgatggac tggcagtcaa tcaaaatcca ggaattgatg tctgatgatc agagagaagc aggtcggatt ccacgaacaa tagaatgtga gcttgttcat gatcttgtgg atagctgtgt cccgggagac acagtgacta ttactggaat tgtcaaagtc tcaaatgcgg aagaaggttc tcgaaataag aatgacaagt gtatgttcct tttgtatatt gaagcaaatt ctattagtaa tagcaaagga cagaaaacaa agagttctga ggatgggtgt aagcatggaa tgttgatgga gttctcactt aaagaccttt atgccatcca agagattcaa gctgaagaaa acctgtttaa actcattgtc aactcgcttt gccctgtcat ttttggtcat gaacttgtta aagcaggttt ggcattagca ctctttggag gaagccagaa atacgcagat gacaaaaaca gaattccaat tcggggagac ccccacatcc ttgttgttgg agatccaggc ctaggaaaaa gtcaaatgct acaggcagcg tgcaatgttg ccccacgtgg cgtgtatgtt tgtggtaaca ccacgaccac ctctggtctg acggtaactc tttcaaaaga tagttcctct ggagattttg ctttggaagc tggtgccctg gtacttggtg atcaaggtat ttgtggaatc gatgaatttg ataagatggg gaatcaacat caagccttgt tggaagccat ggagcagcaa agtattagtc ttgctaaggc tggtgtggtt tgtagccttc ctgcaagaac ttccattatt gctgctgcaa atccagttgg aggacattac aataaagcca aaacagtttc tgagaattta aaaatgggga gtgcactact atccagattt gatttggtct ttatcctgtt agatactcca aatgagcatc atgatcactt actctctgaa catgtgattg caataagagc tggaaagcag agaaccatta gcagtgccac agtagctcgt atgaatagtc aagattcaaa tacttccgta cttgaagtag tttctgagaa gccattatca gaaagactaa aggtggttcc tggagaaaca atagatccca ttccccacca gctattgaga aagtacattg gctatgctcg gcagtatgtg tacccaaggc tatccacaga agctgctcga gttcttcaag atttttacct tgagctccgg aaacagagcc agaggttaaa tagctcacca atcactacca ggcagctgga atctttgatt cgtctgacag aggcacgagc aaggttggaa ttgagagagg aagcaaccaa agaagacgct gaggatatag tggaaattat gaaatatagc atgctaggaa cttactctga tgaatttggg aacctagatt ttgagcgatc ccagcatggt tctggaatga gcaacaggtc aacagcgaaa agatttattt ctgctctcaa caacgttgct gaaagaactt ataataatat atttcaattt catcaacttc ggcagattgc caaagaacta aacattcagg ttgctgattt tgaaaatttt attggatcac taaatgacca gggttacctc ttgaaaaaag gcccaaaagt ttaccagctt caaactatgt aa. It is sometimes possible for the material contained within the vial of "MCM8, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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