KLHL17 cdna clone
KLHL17 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
Uniprot Description
Actinfilin: Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function.
Protein type: Actin-binding; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: actin cytoskeleton; dendrite cytoplasm; extracellular space
Molecular Function: actin filament binding; protein complex scaffold; ubiquitin-protein ligase activity
Biological Process: actin cytoskeleton organization and biogenesis; brain development
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Product Notes
The KLHL17 klhl17 (Catalog #AAA1272959) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagcgaga gccgccagac ccacgtgacg ctgcacgaca tcgaccctca ggccttggac cagctggtgc agtttgccta cacggctgag attgtggtgg gcgagggcaa tgtgcagact ctgctcccag ccgccagtct cctgcagctg aatggcgtcc gagacgcttg ctgcaagttt ctactgagtc agctcgaccc ctccaactgc ctgggtatcc ggggctttgc cgatgcccac tcctgcagcg acctgctcaa ggccgcccac aggtacgtgc tgcagcactt cgtggacgtg gccaagaccg aggagtttat gctgctgccc ctgaaacagg taacagctgg cgggcccagc cctcgccccc caccccaccc caccccagtc tttgtctttg actcccgacc ccgttttgtt cctgacacag ccctgcccac aatccttagt gcctgctgtg tgtccccgag accttcctgg atctgggccc cccaggagcc tcgtctgtgg ctcctgactc tgctcggccc ctcccagtat gaacactcag cccccacctg ctaa. It is sometimes possible for the material contained within the vial of "KLHL17, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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