KDR cdna clone
KDR cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
Uniprot Description
VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; VEGFR family
Chromosomal Location of Human Ortholog: 4q11-q12
Cellular Component: cell junction; early endosome; endoplasmic reticulum; endosome; Golgi apparatus; integral to plasma membrane; lipid raft; plasma membrane
Molecular Function: growth factor binding; Hsp90 protein binding; integrin binding; protein binding; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity
Biological Process: angiogenesis; cell migration during sprouting angiogenesis; embryonic hemopoiesis; extracellular matrix organization and biogenesis; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of focal adhesion formation; positive regulation of macroautophagy; positive regulation of MAPKKK cascade; positive regulation of mitochondrial depolarization; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of positive chemotaxis; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; regulation of cell shape; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vasculogenesis
Disease: Hemangioma, Capillary Infantile
Research Articles on KDR
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Product Notes
The KDR kdr (Catalog #AAA1268225) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCAGAGCA AGGTGCTGCT GGCCGTCGCC CTGTGGCTCT GCGTGGAGAC CCGGGCCGCC TCTGTGGGTT TGCCTAGTGT TTCTCTTGAT CTGCCCAGGC TCAGCATACA AAAAGACATA CTTACAATTA AGGCTAATAC AACTCTTCAA ATTACTTGCA GGGGACAGAG GGACTTGGAC TGGCTTTGGC CCAATAATCA GAGTGGCAGT GAGCAAAGGG TGGAGGTGAC TGAGTGCAGC GATGGCCTCT TCTGTAAGAC ACTCACAATT CCAAAAGTGA TCGGAAATGA CACTGGAGCC TACAAGTGCT TCTACCGGGA AACTGACTTG GCCTCGGTCA TTTATGTCTA TGTTCAAGAT TACAGATCTC CATTTATTGC TTCTGTTAGT GACCAACATG GAGTCGTGTA CATTACTGAG AACAAAAACA AAACTGTGGT GATTCCATGT CTCGGGTCCA TTTCAAATCT CAACGTGTCA CTTTGTGCAA GATACCCAGA AAAGAGATTT GTTCCTGATG GTAACAGAAT TTCCTGGGAC AGCAAGAAGG GCTTTACTAT TCCCAGCTAC ATGATCAGCT ATGCTGGCAT GGTCTTCTGT GAAGCAAAAA TTAATGATGA AAGTTACCAG TCTATTATGT ACATAGTTGT CGTTGTAGGG TATAGGATTT ATGATGTGGT TCTGAGTCCG TCTCATGGAA TTGAACTATC TGTTGGAGAA AAGCTTGTCT TAAATTGTAC AGCAAGAACT GAACTAAATG TGGGGATTGA CTTCAACTGG GAATACCCTT CTTCGAAGCA TCAGCATAAG AAACTTGTAA ACCGAGACCT AAAAACCCAG TCTGGGAGTG AGATGAAGAA ATTTTTGAGC ACCTTAACTA TAGATGGTAT AACCCGGAGT GACCAAGGAT TGTACACCTG TGCAGCATCC AGTGGGCTGA TGACCAAGAA GAACAGCACA TTTGTCAGGG TCCATGAAAA ACCTTTTGTT GCTTTTGGAA GTGGCATGGA ATCTCTGGTG GAAGCCACGG TGGGGGAGCG TGTCAGAATC CCTGCGAAGT ACCTTGGTTA CCCACCCCCA GAAATAAAAT GGTATAAAAA TGGAATACCC CTTGAGTCCA ATCACACAAT TAAAGCGGGG CATGTACTGA CGATTATGGA AGTGAGTGAA AGAGACACAG GAAATTACAC TGTCATCCTT ACCAATCCCA TTTCAAAGGA GAAGCAGAGC CATGTGGTCT CTCTGGTTGT GTATGTCCCA CCCCAGATTG GTGAGAAATC TCTAATCTCT CCTGTGGATT CCTACCAGTA CGGCACCACT CAAACGCTGA CATGTACGGT CTATGCCATT CCTCCCCCGC ATCACATCCA CTGGTATTGG CAGTTGGAGG AAGAGTGCGC CAACGAGCCC AGCCATGCTG TCTCAGTGAC AAACCCATAC CCTTGTGAAG AATGGAGAAG TGTGGAGGAC TTCCAGGGAG GAAATAAAAT TGAAGTTAAT AAAAATCAAT TTGCTCTAAT TGAAGGAAAA AACAAAACTG TAAGTACCCT TGTTATCCAA GCGGCAAATG TGTCAGCTTT GTACAAATGT GAAGCGGTCA ACAAAGTCGG GAGAGGAGAG AGGGTGATCT CCTTCCACGT GACCAGGGGT CCTGAAATTA CTTTGCAACC TGACATGCAG CCCACTGAGC AGGAGAGCGT GTCTTTGTGG TGCACTGCAG ACAGATCTAC GTTTGAGAAC CTCACATGGT ACAAGCTTGG CCCACAGCCT CTGCCAATCC ATGTGGGAGA GTTGCCCACA CCTGTTTGCA AGAACTTGGA TACTCTTTGG AAATTGAATG CCACCATGTT CTCTAATAGC ACAAATGACA TTTTGATCAT GGAGCTTAAG AATGCATCCT TGCAGGACCA AGGAGACTAT GTCTGCCTTG CTCAAGACAG GAAGACCAAG AAAAGACATT GCGTGGTCAG GCAGCTCACA GTCCTAGAGC GTGTGGCACC CACGATCACA GGAAACCTGG AGAATCAGAC GACAAGTATT GGGGAAAGCA TCGAAGTCTC ATGCACGGCA TCTGGGAATC CCCCTCCACA GATCATGTGG TTTAAAGATA ATGAGACCCT TGTAGAAGAC TCAGGCATTG TATTGAAGGA TGGGAACCGG AACCTCACTA TCCGCAGAGT GAGGAAGGAG GACGAAGGCC TCTACACCTG CCAGGCATGC AGTGTTCTTG GCTGTGCAAA AGTGGAGGCA TTTTTCATAA TAGAAGGTGC CCAGGAAAAG ACGAACTTGG AAATCATTAT TCTAGTAGGC ACGGCGGTGA TTGCCATGTT CTTCTGGCTA CTTCTTGTCA TCATCCTACG GACCGTTAAG CGGGCCAATG GAGGGGAACT GAAGACAGGC TACTTGTCCA TCGTCATGGA TCCAGATGAA CTCCCATTGG ATGAACATTG TGAACGACTG CCTTATGATG CCAGCAAATG GGAATTCCCC AGAGACCGGC TGAAGCTAGG TAAGCCTCTT GGCCGTGGTG CCTTTGGCCA AGTGATTGAA GCAGATGCCT TTGGAATTGA CAAGACAGCA ACTTGCAGGA CAGTAGCAGT CAAAATGTTG AAAGAAGGAG CAACACACAG TGAGCATCGA GCTCTCATGT CTGAACTCAA GATCCTCATT CATATTGGTC ACCATCTCAA TGTGGTCAAC CTTCTAGGTG CCTGTACCAA GCCAGGAGGG CCACTCATGG TGATTGTGGA ATTCTGCAAA TTTGGAAACC TGTCCACTTA CCTGAGGAGC AAGAGAAATG AATTTGTCCC CTACAAGACC AAAGGGGCAC GATTCCGTCA AGGGAAAGAC TACGTTGGAG CAATCCCTGT GGATCTGAAA CGGCGCTTGG ACAGCATCAC CAGTAGCCAG AGCTCAGCCA GCTCTGGATT TGTGGAGGAG AAGTCCCTCA GTGATGTAGA AGAAGAGGAA GCTCCTGAAG ATCTGTATAA GGACTTCCTG ACCTTGGAGC ATCTCATCTG TTACAGCTTC CAAGTGGCTA AGGGCATGGA GTTCTTGGCA TCGCGAAAGT GTATCCACAG GGACCTGGCG GCACGAAATA TCCTCTTATC GGAGAAGAAC GTGGTTAAAA TCTGTGACTT TGGCTTGGCC CGGGATATTT ATAAAGATCC AGATTATGTC AGAAAAGGAG ATGCTCGCCT CCCTTTGAAA TGGATGGCCC CAGAAACAAT TTTTGACAGA GTGTACACAA TCCAGAGTGA CGTCTGGTCT TTTGGTGTTT TGCTGTGGGA AATATTTTCC TTAGGTGCTT CTCCATATCC TGGGGTAAAG ATTGATGAAG AATTTTGTAG GCGATTGAAA GAAGGAACTA GAATGAGGGC CCCTGATTAT ACTACACCAG AAATGTACCA GACCATGCTG GACTGCTGGC ACGGGGAGCC CAGTCAGAGA CCCACGTTTT CAGAGTTGGT GGAACATTTG GGAAATCTCT TGCAAGCTAA TGCTCAGCAG GATGGCAAAG ACTACATTGT TCTTCCGATA TCAGAGACTT TGAGCATGGA AGAGGATTCT GGACTCTCTC TGCCTACCTC ACCTGTTTCC TGTATGGAGG AGGAGGAAGT ATGTGACCCC AAATTCCATT ATGACAACAC AGCAGGAATC AGTCAGTATC TGCAGAACAG TAAGCGAAAG AGCCGGCCTG TGAGTGTAAA AACATTTGAA GATATCCCGT TAGAAGAACC AGAAGTAAAA GTAATCCCAG ATGACAACCA GACGGACAGT GGTATGGTTC TTGCCTCAGA AGAGCTGAAA ACTTTGGAAG ACAGAACCAA ATTATCTCCA TCTTTTGGTG GAATGGTGCC CAGCAAAAGC AGGGAGTCTG TGGCATCTGA AGGCTCAAAC CAGACAAGCG GCTACCAGTC CGGATATCAC TCCGATGACA CAGACACCAC CGTGTACTCC AGTGAGGAAG CAGAACTTTT AAAGCTGATA GAGATTGGAG TGCAAACCGG TAGCACAGCC CAGATTCTCC AGCCTGACTC GGGGACCACA CTGAGCTCTC CTCCTGTTTA A. It is sometimes possible for the material contained within the vial of "KDR, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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