HPSE cdna clone
HPSE cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Description
HPSE: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up- regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis. Belongs to the glycosyl hydrolase 79 family.
Protein type: EC 3.2.1.166; Glycan Metabolism - glycosaminoglycan degradation; Extracellular matrix; Hydrolase; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q21.3
Cellular Component: intracellular membrane-bound organelle; lysosomal lumen; lysosome; nucleoplasm; nucleus; proteinaceous extracellular matrix
Molecular Function: beta-glucuronidase activity; heparan sulfate proteoglycan binding; heparanase activity; protein binding; protein dimerization activity; syndecan binding
Biological Process: angiogenesis involved in wound healing; cell-matrix adhesion; extracellular matrix organization and biogenesis; glycosaminoglycan catabolic process; heparan sulfate proteoglycan catabolic process; positive regulation of blood coagulation; positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling cascade; proteoglycan metabolic process; regulation of hair follicle development
Research Articles on HPSE
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Product Notes
The HPSE hpse (Catalog #AAA1269557) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgctgctgc gctcgaagcc tgcgctgccg ccgccgctga tgctgctgct cctggggccg ctgggtcccc tctcccctgg cgccctgccc cgacctgcgc aagcacagga cgtcgtggac ctggacttct tcacccagga gccgctgcac ctggtgagcc cctcgttcct gtccgtcacc attgacgcca acctggccac ggacccgcgg ttcctcatcc tcctgggttc tccaaagctt cgtaccttgg ccagaggctt gtctcctgcg tacctgaggt ttggtggcac caagacagac ttcctaattt tcgatcccaa gaaggaatca acctttgaag agagaagtta ctggcaatct caagtcaacc aggatatttg caaatatgga tccatccctc ctgatgtgga ggagaagtta cggttggaat ggccctacca ggagcaattg ctactccgag aacactacca gaaaaagttc aagaacagca cctactcaag aagctctgta gatgtgctat acacttttgc aaactgctca ggactggact tgatctttgg cctaaatgcg ttattaagaa cagcagattt gcagtggaac agttctaatg ctcagttgct cctggactac tgctcttcca aggggtataa catttcttgg gaactaggca atgaacctaa cagtttcctt aagaaggctg atattttcat caatgggtcg cagttaggag aagattttat tcaattgcat aaacttctaa gaaagtccac cttcaaaaat gcaaaactct atggtcctga tgttggtcag cctcgaagaa agacggctaa gatgctgaag agcttcctga aggctggtgg agaagtgatt gattcagtta catggcatca ctactatttg aatggacgga ctgctaccag ggaagatttt ctaaaccctg atgtattgga catttttatt tcatctgtgc aaaaagtttt ccaggtggtt gagagcacca ggcctggcaa gaaggtctgg ttaggagaaa caagctctgc atatggaggc ggagcgccct tgctatccga cacctttgca gctggcttta tgtggctgga taaattgggc ctgtcagccc gaatgggaat agaagtggtg atgaggcaag tattctttgg agcaggaaac taccatttag tggatgaaaa cttcgatcct ttacctgatt attggctatc tcttctgttc aagaaattgg tgggcaccaa ggtgttaatg gcaagcgtgc aaggttcaaa gagaaggaag cttcgagtat accttcattg cacaaacact gacaatccaa ggtataaaga aggagattta actctgtatg ccataaacct ccataatgtc accaagtact tgcggttacc ctatcctttt tctaacaagc aagtggataa ataccttcta agacctttgg gacctcatgg attactttcc aaatctgtcc aactcaatgg tctaactcta aagatggtgg atgatcaaac cttgccacct ttaatggaaa aacctctccg gccaggaagt tcactgggct tgccagcttt ctcatatagt ttttttgtga taagaaatgc caaagttgct gcttgcatct ga. It is sometimes possible for the material contained within the vial of "HPSE, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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