GRIN2B cdna clone
GRIN2B cDNA Clone
Gene Names
GRIN2B; MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B
Synonyms
GRIN2B; GRIN2B cDNA Clone; GRIN2B cdna clone
Sequence
atgaagcccagagcggagtgctgttctcccaagttctggttggtgttggccgtcctggccgtgtcaggcagcagagctcgttctcagaagagcccccccagcattggcattgctgtcatcctcgtgggcacttccgacgaggtggccatcaaggatgcccacgagaaagatgatttccaccatctctccgtggtaccccgggtggaactggtagccatgaatgagaccgacccaaagagcatcatcacccgcatctgtgatctcatgtctgaccggaagatccagggggtggtgtttgctgatgacacagaccaggaagccatcgcccagatcctcgatttcatttcagcacagactctcaccccgatcctgggcatccacgggggctcctctatgataatggcagataaggatgaatcctccatgttcttccagtttggcccatcaattgaacagcaagcttccgtaatgctcaacatcatggaagaatatgactggtacatcttttctatcgtcaccacctatttccctggctaccaggactttgtaaacaagatccgcagcaccattgagaatagctttgtgggctgggagctagaggaggtcctcctactggacatgtccctggacgatggagattctaagatccagaatcagctcaagaaacttcaaagccccatcattcttctttactgtaccaaggaagaagccacctacatctttgaagtggccaactcagtagggctgactggctatggctacacgtggatcgtgcccagtctggtggcaggggatacagacacagtgcctgcggagttccccactgggctcatctctgtatcatatgatgaatgggactatggcctccccgccagagtgagagatggaattgccataatcaccactgctgcttctgacatgctgtctgagcacagcttcatccctgagcccaaaagcagttgttacaacacccacgagaagagaatctaccagtccaatatgctaaataggtatctgatcaatgtcacttttgaggggaggaatttgtccttcagtgaagatggctaccagatgcacccgaaactggtgataattcttctgaacaaggagaggaagtgggaaagggtggggaagtggaaagacaagtccctgcagatgaagtactatgtgtggccccgaatgtgtccagagactgaagagcaggaggatgaccatctgagcattgtgaccctggaggaggcaccatttgtcattgtggaaagtgtggaccctctgagtggaacctgcatgaggaacacagtcccctgccaaaaacgcatagtcactgagaataaaacagacgaggagccgggttacatcaaaaaatgctgcaaggggttctgtattgacatccttaagaaaatttctaaatctgtgaagttcacctatgacctttacctggttaccaatggcaagcatgggaagaaaatcaatggaacctggaatggtatgattggagaggtggtcatgaagagggcctacatggcagtgggctcactcaccatcaatgaggaacgatcggaggtggtcgacttctctgtgcccttcatagagacaggcatcagtgtcatggtgtcacgcagcaatgggactgtctcaccttctgccttcttagagccattcagtgctgacgtatgggtgatgatgtttgtgatgctgctcatcgtctcagccgtggctgtctttgtctttgagtacttcagccctgtgggttataacaggtgcctcgctgatggcagagagcctggtggaccctctttcaccatcggcaaagctatttggttgctctggggtctggtgtttaacaactccgtacctgtgcagaacccaaaggggaccacctccaagatcatggtgtcagtgtgggccttctttgctgtcatcttcctggccagctacactgccaacttagctgccttcatgatccaagaggaatatgtggaccaggtttctggcctgagcgacaaaaagttccagagacctaatgacttctcaccccctttccgctttgggaccgtgcccaacggcagcacagagagaaatattcgcaataactatgcagaaatgcatgcctacatgggaaagttcaaccagaggggtgtagatgatgcattgctctccctgaaaacagggaaactggatgccttcatctatgatgcagcagtgctgaactatatggcaggcagagatgaaggctgcaagctggtgaccattggcagtgggaaggtctttgcttccactggctatggcattgccatccaaaaagattctgggtggaagcgccaggtggaccttgctatcctgcagctctttggagatggggagatggaagaactggaagctctctggctcactggcatttgtcacaatgagaagaatgaggtcatgagcagccagctggacattgacaacatggcaggggtcttctacatgttgggggcggccatggctctcagcctcatcaccttcatctgcgaacaccttttctattggcagttccgacattgctttatgggtgtctgttctggcaagcctggcatggtcttctccatcagcagaggtatctacagctgcatccatggggtggcgatcgaggagcgccagtctgtaatgaactcccccaccgcaaccatgaacaacacacactccaacatcctgcgcctgctgcgcacggccaagaacatggctaacctgtctggtgtgaatggctcaccgcagagcgccctggacttcatccgacgggagtcatccgtctatgacatctcagagcaccgccgcagcttcacgcattctgactgcaaatcctacaacaacccgccctgtgaggagaacctcttcagtgactacatcagtgaggtagagagaacgttcgggaacctgcagctgaaggacagcaacgtgtaccaagatcactaccaccatcaccaccggccccatagtattggcagtgccagctccatcgatgggctctacgactgtgacaacccacccttcaccacccagtccaggtccatcagcaagaagcccctggacatcggcctcccctcctccaagcacagccagctcagtgacctgtacggcaaattctccttcaagagcgaccgctacagtggccacgacgacttgatccgctccgatgtctctgacatctcaacccacaccgtcacctatgggaacatcgagggcaatgccgccaagaggcgtaagcagcaatataaggacagcctgaagaagcggcctgcctcggccaagtcccgcagggagtttgacgagatcgagctggcctaccgtcgccgaccgccccgctcccctgaccacaagcgctacttcagggacaaggaagggctacgggacttctacctggaccagttccgaacaaaggagaactcaccccactgggagcacgtagacctgaccgacatctacaaggagcggagtgatgactttaagcgcgactccgtcagcggaggagggccctgtaccaacaggtctcatatcaagcacgggacgggcgacaaacacggcgtggtcagcggggtacctgcaccttgggagaagaacctgaccaacgtggagtgggaggaccggtccgggggcaacttctgccgcagctgtccctccaagctgcacaactactccacgacggtgacgggtcagaactcgggcaggcaggcgtgcatccggtgtgaggcttgcaagaaagcaggcaacctgtatgacatcagtgaggacaactccctgcaggaactggaccagccggctgccccagtggcggtgacgtcaaacgcctccaccactaagtaccctcagagcccgactaattccaaggcccagaagaagaaccggaacaaactgcgccggcagcactcctacgacaccttcgtggacctgcagaaggaagaagccgccctggccccgcgcagcgtaagcctgaaagacaagggccgattcatggatgggagcccctacgcccacatgtttgagatgtcagctggcgagagcacctttgccaacaacaagtcctcagtgcccactgccggacatcaccaccacaacaaccccggcggcgggtacatgctcagcaagtcgctctaccctgaccgggtcacgcaaaaccctttcatccccacttttggggacgaccagtgcttgctccatggcagcaaatcctacttcttcaggcagcccacggtggcgggggcgtcgaaagccaggccggacttccgggcccttgtcaccaacaagccggtggtctcggcccttcatggggccgtgccagcccgtttccagaaggacatctgtatagggaaccagtccaacccctgtgtgcctaacaacaaaaaccccagggctttcaatggctccagcaatgggcatgtttatgagaaactttctagtattgagtctgatgtctga
Sequence Length
4455
Vector
pUC
Clone Sequence Report
Provided with product shipment
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
166,367 Da
NCBI Official Full Name
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B, mRNA
NCBI Official Synonym Full Names
glutamate ionotropic receptor NMDA type subunit 2B
NCBI Official Symbol
GRIN2B
NCBI Official Synonym Symbols
MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2B
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2B
Protein Family
UniProt Gene Name
GRIN2B
UniProt Synonym Gene Names
NMDAR2B; GluN2B; NMDAR2B; NR2B; NR3; hNR3
UniProt Entry Name
NMDE2_HUMAN
NCBI Description
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
Uniprot Description
NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.
Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium
Chromosomal Location of Human Ortholog: 12p12
Cellular Component: cell surface; integral to plasma membrane; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane
Molecular Function: glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process: ephrin receptor signaling pathway; glutamate signaling pathway; learning and/or memory; MAPKKK cascade; response to ethanol; synaptic transmission; transport
Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6
Research Articles on GRIN2B
Similar Products
Product Notes
The GRIN2B grin2b (Catalog #AAA1267817) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc accccgatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag caggaggatg accatctgag cattgtgacc ctggaggagg caccatttgt cattgtggaa agtgtggacc ctctgagtgg aacctgcatg aggaacacag tcccctgcca aaaacgcata gtcactgaga ataaaacaga cgaggagccg ggttacatca aaaaatgctg caaggggttc tgtattgaca tccttaagaa aatttctaaa tctgtgaagt tcacctatga cctttacctg gttaccaatg gcaagcatgg gaagaaaatc aatggaacct ggaatggtat gattggagag gtggtcatga agagggccta catggcagtg ggctcactca ccatcaatga ggaacgatcg gaggtggtcg acttctctgt gcccttcata gagacaggca tcagtgtcat ggtgtcacgc agcaatggga ctgtctcacc ttctgccttc ttagagccat tcagtgctga cgtatgggtg atgatgtttg tgatgctgct catcgtctca gccgtggctg tctttgtctt tgagtacttc agccctgtgg gttataacag gtgcctcgct gatggcagag agcctggtgg accctctttc accatcggca aagctatttg gttgctctgg ggtctggtgt ttaacaactc cgtacctgtg cagaacccaa aggggaccac ctccaagatc atggtgtcag tgtgggcctt ctttgctgtc atcttcctgg ccagctacac tgccaactta gctgccttca tgatccaaga ggaatatgtg gaccaggttt ctggcctgag cgacaaaaag ttccagagac ctaatgactt ctcaccccct ttccgctttg ggaccgtgcc caacggcagc acagagagaa atattcgcaa taactatgca gaaatgcatg cctacatggg aaagttcaac cagaggggtg tagatgatgc attgctctcc ctgaaaacag ggaaactgga tgccttcatc tatgatgcag cagtgctgaa ctatatggca ggcagagatg aaggctgcaa gctggtgacc attggcagtg ggaaggtctt tgcttccact ggctatggca ttgccatcca aaaagattct gggtggaagc gccaggtgga ccttgctatc ctgcagctct ttggagatgg ggagatggaa gaactggaag ctctctggct cactggcatt tgtcacaatg agaagaatga ggtcatgagc agccagctgg acattgacaa catggcaggg gtcttctaca tgttgggggc ggccatggct ctcagcctca tcaccttcat ctgcgaacac cttttctatt ggcagttccg acattgcttt atgggtgtct gttctggcaa gcctggcatg gtcttctcca tcagcagagg tatctacagc tgcatccatg gggtggcgat cgaggagcgc cagtctgtaa tgaactcccc caccgcaacc atgaacaaca cacactccaa catcctgcgc ctgctgcgca cggccaagaa catggctaac ctgtctggtg tgaatggctc accgcagagc gccctggact tcatccgacg ggagtcatcc gtctatgaca tctcagagca ccgccgcagc ttcacgcatt ctgactgcaa atcctacaac aacccgccct gtgaggagaa cctcttcagt gactacatca gtgaggtaga gagaacgttc gggaacctgc agctgaagga cagcaacgtg taccaagatc actaccacca tcaccaccgg ccccatagta ttggcagtgc cagctccatc gatgggctct acgactgtga caacccaccc ttcaccaccc agtccaggtc catcagcaag aagcccctgg acatcggcct cccctcctcc aagcacagcc agctcagtga cctgtacggc aaattctcct tcaagagcga ccgctacagt ggccacgacg acttgatccg ctccgatgtc tctgacatct caacccacac cgtcacctat gggaacatcg agggcaatgc cgccaagagg cgtaagcagc aatataagga cagcctgaag aagcggcctg cctcggccaa gtcccgcagg gagtttgacg agatcgagct ggcctaccgt cgccgaccgc cccgctcccc tgaccacaag cgctacttca gggacaagga agggctacgg gacttctacc tggaccagtt ccgaacaaag gagaactcac cccactggga gcacgtagac ctgaccgaca tctacaagga gcggagtgat gactttaagc gcgactccgt cagcggagga gggccctgta ccaacaggtc tcatatcaag cacgggacgg gcgacaaaca cggcgtggtc agcggggtac ctgcaccttg ggagaagaac ctgaccaacg tggagtggga ggaccggtcc gggggcaact tctgccgcag ctgtccctcc aagctgcaca actactccac gacggtgacg ggtcagaact cgggcaggca ggcgtgcatc cggtgtgagg cttgcaagaa agcaggcaac ctgtatgaca tcagtgagga caactccctg caggaactgg accagccggc tgccccagtg gcggtgacgt caaacgcctc caccactaag taccctcaga gcccgactaa ttccaaggcc cagaagaaga accggaacaa actgcgccgg cagcactcct acgacacctt cgtggacctg cagaaggaag aagccgccct ggccccgcgc agcgtaagcc tgaaagacaa gggccgattc atggatggga gcccctacgc ccacatgttt gagatgtcag ctggcgagag cacctttgcc aacaacaagt cctcagtgcc cactgccgga catcaccacc acaacaaccc cggcggcggg tacatgctca gcaagtcgct ctaccctgac cgggtcacgc aaaacccttt catccccact tttggggacg accagtgctt gctccatggc agcaaatcct acttcttcag gcagcccacg gtggcggggg cgtcgaaagc caggccggac ttccgggccc ttgtcaccaa caagccggtg gtctcggccc ttcatggggc cgtgccagcc cgtttccaga aggacatctg tatagggaac cagtccaacc cctgtgtgcc taacaacaaa aaccccaggg ctttcaatgg ctccagcaat gggcatgttt atgagaaact ttctagtatt gagtctgatg tctga. It is sometimes possible for the material contained within the vial of "GRIN2B, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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