GNRHR cdna clone
GNRHR cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GNRHR: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. Defects in GNRHR are a cause of idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. Defects in GNRHR are a cause of fertile eunuch syndrome (FEUNS). Fertile eunuch syndrome is a mild phenotypic form of HH going with the presence of normal testicular size and some degree of spermatogenesis. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 4q21.2
Cellular Component: integral to plasma membrane; membrane; plasma membrane
Molecular Function: peptide binding
Biological Process: multicellular organismal development
Disease: Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
Research Articles on GNRHR
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Product Notes
The GNRHR gnrhr (Catalog #AAA1266787) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcaaaca gtgcctctcc tgaacagaat caaaatcact gttcagccat caacaacagc atcccactga tgcagggcaa cctccccact ctgaccttgt ctggaaagat ccgagtgacg gttactttct tcctttttct gctctctgcg acctttaatg cttctttctt gttgaaactt cagaagtgga cacagaagaa agagaaaggg aaaaagctct caagaatgaa gctgctctta aaacatctga ccttagccaa cctgttggag actctgattg tcatgccact ggatgggatg tggaacatta cagtccaatg gtatgctgga gagttactct gcaaagttct cagttatcta aagcttttct ccatgtatgc cccagccttc atgatggtgg tgatcagcct ggaccgctcc ctggctatca cgaggcccct agctttgaaa agcaacagca aagtcggaca gtccatggtt ggcctggcct ggatcctcag tagtgtcttt gcaggaccac agttatacat cttcaggatg attcatctag cagacagctc tggacagaca aaagttttct ctcaatgtgt aacacactgc agtttttcac aatggtggca tcaagcattt tataactttt tcaccttcag ctgcctcttc atcatccctc ttttcatcat gctgatctgc aatgcaaaaa tcatcttcac cctgacacgg gtccttcatc aggaccccca cgaactacaa ctgaatcagt ccaagaacaa tataccaaga gcacggctga agactctaaa aatgacggtt gcatttgcca cttcatttac tgtctgctgg actccctact atgtcctagg aatttggtat tggtttgatc ctgaaatgtt aaacaggttg tcagacccag taaatcactt cttctttctc tttgcctttt taaacccatg ctttgatcca cttatctatg gatatttttc tctgtga. It is sometimes possible for the material contained within the vial of "GNRHR, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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