GDF5 cdna clone
GDF5 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016]
Uniprot Description
GDF5: a cytokine that is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. These cytokines are characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Binds to bone morphogenetic protein receptors (BMPRs), a family of transmembrane serine/threonine kinases. BMPRs are involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG), acromesomelic chondrodysplasia Hunter-Thompson type (AMDH), brachydactyly type C (BDC), Du Pan syndrome (DPS), symphalangism proximal syndrome (SYM1), multiple synostoses syndrome type 2 (SYNS2), and brachydactyly type A2 (BDA2). Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5). Belongs to the TGF-beta family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; identical protein binding; protein binding; transforming growth factor beta receptor binding
Biological Process: cell development; cell-cell signaling; negative regulation of chondrocyte differentiation; negative regulation of epithelial cell proliferation; positive regulation of BMP signaling pathway; positive regulation of chondrocyte differentiation; regulation of apoptosis; regulation of MAPKKK cascade; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway
Disease: Acromesomelic Dysplasia, Hunter-thompson Type; Brachydactyly, Type A1, C; Brachydactyly, Type A2; Brachydactyly, Type C; Chondrodysplasia, Grebe Type; Fibular Hypoplasia And Complex Brachydactyly; Multiple Synostoses Syndrome 2; Osteoarthritis Susceptibility 5; Symphalangism, Proximal, 1b
Research Articles on GDF5
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Product Notes
The GDF5 gdf5 (Catalog #AAA1275731) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgagactcc ccaaactcct cactttcttg ctttggtacc tggcttggct ggacctggaa ttcatctgca ctgtgttggg tgcccctgac ttgggccaga gaccccaggg gaccaggcca ggattggcca aagcagaggc caaggagagg ccccccctgg cccggaacgt cttcaggcca gggggtcaca gctatggtgg gggggccacc aatgccaatg ccagggcaaa gggaggcacc gggcagacag gaggcctgac acagcccaag aaggatgaac ccaaaaagct gccccccaga ccgggcggcc ctgaacccaa gccaggacac cctccccaaa caaggcaggc tacagcccgg actgtgaccc caaaaggaca gcttcccgga ggcaaggcac ccccaaaagc aggatctgtc cccagctcct tcctgctgaa gaaggccagg gagcccgggc ccccacgaga gcccaaggag ccgtttcgcc caccccccat cacaccccac gagtacatgc tctcgctgta caggacgctg tccgatgctg acagaaaggg aggcaacagc agcgtgaagt tggaggctgg cctggccaac accatcacca gctttattga caaagggcaa gatgaccgag gtcccgtggt caggaagcag aggtacgtgt ttgacattag tgccctggag aaggatgggc tgctgggggc cgagctgcgg atcttgcgga agaagccctc ggacacggcc aagccagcgg cccccggagg cgggcgggct gcccagctga agctgtccag ctgccccagc ggccggcagc cggcctcctt gctggatgtg cgctccgtgc caggcctgga cggatctggc tgggaggtgt tcgacatctg gaagctcttc cgaaacttta agaactcggc ccagctgtgc ctggagctgg aggcctggga acggggcagg gccgtggacc tccgtggcct gggcttcgac cgcgccgccc ggcaggtcca cgagaaggcc ctgttcctgg tgtttggccg caccaagaaa cgggacctgt tctttaatga gattaaggcc cgctctggcc aggacgataa gaccgtgtat gagtacctgt tcagccagcg gcgaaaacgg cgggccccac tggccactcg ccagggcaag cgacccagca agaaccttaa ggctcgctgc agtcggaagg cactgcatgt caacttcaag gacatgggct gggacgactg gatcatcgca ccccttgagt acgaggcttt ccactgcgag gggctgtgcg agttcccatt gcgctcccac ctggagccca cgaatcatgc agtcatccag accctgatga actccatgga ccccgagtcc acaccaccca cctgctgtgt tcccacgcgg ctgagtccca tcagcatcct cttcattgac tctgccaaca acgtggtgta taagcagtat gaggacatgg tcgtggagtc gtgtggctgc aggtag. It is sometimes possible for the material contained within the vial of "GDF5, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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