Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human ovarian cancer using at dilution of 1:100.)
Rabbit anti-Human GDF5 Polyclonal Antibody | anti-GDF5 antibody
GDF5 Polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human ovarian cancer using at dilution of 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human ovarian cancer using at dilution of 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human rectal cancer using at dilution of 1:100.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human rectal cancer using at dilution of 1:100.)
NCBI and Uniprot Product Information
Uniprot Description
GDF5: a cytokine that is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. These cytokines are characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Binds to bone morphogenetic protein receptors (BMPRs), a family of transmembrane serine/threonine kinases. BMPRs are involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG), acromesomelic chondrodysplasia Hunter-Thompson type (AMDH), brachydactyly type C (BDC), Du Pan syndrome (DPS), symphalangism proximal syndrome (SYM1), multiple synostoses syndrome type 2 (SYNS2), and brachydactyly type A2 (BDA2). Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5). Belongs to the TGF-beta family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; identical protein binding; protein binding; transforming growth factor beta receptor binding
Biological Process: cell development; cell-cell signaling; negative regulation of chondrocyte differentiation; negative regulation of epithelial cell proliferation; positive regulation of BMP signaling pathway; positive regulation of chondrocyte differentiation; regulation of apoptosis; regulation of MAPKKK cascade; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway
Disease: Acromesomelic Dysplasia, Hunter-thompson Type; Brachydactyly, Type A1, C; Brachydactyly, Type A2; Brachydactyly, Type C; Chondrodysplasia, Grebe Type; Fibular Hypoplasia And Complex Brachydactyly; Multiple Synostoses Syndrome 2; Osteoarthritis Susceptibility 5; Symphalangism, Proximal, 1b
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Product Notes
The GDF5 gdf5 (Catalog #AAA9415256) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GDF5 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GDF5 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the GDF5 gdf5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GDF5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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