EFNA4 cdna clone
EFNA4 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
EFNA4: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. Belongs to the ephrin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: extracellular region; integral to plasma membrane; plasma membrane
Molecular Function: ephrin receptor binding; protein binding; transmembrane-ephrin receptor activity
Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway
Research Articles on EFNA4
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Product Notes
The EFNA4 efna4 (Catalog #AAA1275526) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCGGCTGC TGCCCCTGCT GCGGACTGTC CTCTGGGCCG CGTTCCTCGG CTCCCCTCTG CGCGGGGGCT CCAGCCTCCG CCACGTAGTC TACTGGAACT CCAGTAACCC CAGGTTGCTT CGAGGAGACG CCGTGGTGGA GCTGGGCCTC AACGATTACC TAGACATTGT CTGCCCCCAC TACGAAGGCC CAGGGCCCCC TGAGGGCCCC GAGACGTTTG CTTTGTACAT GGTGGACTGG CCAGGCTATG AGTCCTGCCA GGCAGAGGGC CCCCGGGCCT ACAAGCGCTG GGTGTGCTCC CTGCCCTTTG GCCATGTTCA ATTCTCAGAG AAGATTCAGC GCTTCACACC CTTCTCCCTC GGCTTTGAGT TCTTACCTGG AGAGACTTAC TACTACATCT CGGTGCCCAC TCCAGAGAGT TCTGGCCAGT GCTTGAGGCT CCAGGTGTCT GTCTGCTGCA AGGAGAGGAA GTCTGAGTCA GCCCATCCTG TTGGGAGCCC TGGAGAGAGT GGCACATCAG GGTGGCGAGG GGGGGACACT CCCAGCCCCC TCTGTCTCTT GCTATTACTG CTGCTTCTGA TTCTTCGTCT TCTGCGAATT CTGTGA. It is sometimes possible for the material contained within the vial of "EFNA4, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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