DUSP26 cdna clone
DUSP26 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Description
DUSP26: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.16
Chromosomal Location of Human Ortholog: 8p12
Cellular Component: cytoplasm; Golgi apparatus; nucleus
Molecular Function: p53 binding; phosphoprotein phosphatase activity; phosphoserine phosphatase activity; protein binding; protein tyrosine phosphatase activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell adhesion; protein amino acid dephosphorylation
Research Articles on DUSP26
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Product Notes
The DUSP26 dusp26 (Catalog #AAA1269765) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtgccctg gtaactggct ttgggcttct atgactttta tggcccgctt ctcccggagt agctcaaggt ctcctgttcg aactcgaggg accctggagg agatgccaac cgttcaacat cctttcctca atgtcttcga gttggagcgg ctcctctaca caggcaagac agcctgtaac catgccgacg aggtctggcc aggcctctat ctcggagacc aggacatggc taacaaccgc cgggagcttc gccgcctggg catcacgcac gtcctcaatg cctcacacag ccggtggcga ggcacgcccg aggcctatga ggggctgggc atccgctacc tgggtgttga ggcccacgac tcgccagcct ttgacatgag catccacttc cagacggctg ccgacttcat ccaccgggcg ctgagccagc caggagggaa gatcctggtg cattgtgctg tgggcgtgag ccgatccgcc accctggtac tggcctacct catgctgtac caccacctta ccctcgtgga ggccatcaag aaagtcaaag accaccgagg catcatcccc aaccggggct tcctgaggca gctcctggcc ctggaccgca ggctgcggca gggtctggaa gcatga. It is sometimes possible for the material contained within the vial of "DUSP26, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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