DTD1 cdna clone
DTD1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein binds the DNA unwinding element and plays a role in the initiation of DNA replication. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Description
DTD1: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential). Belongs to the DTD family.
Protein type: DNA replication; EC 3.1.-.-; Hydrolase
Chromosomal Location of Human Ortholog: 20p11.23
Cellular Component: cytoplasm
Molecular Function: D-tyrosyl-tRNA(Tyr) deacylase activity
Biological Process: tRNA metabolic process