Human Complement Factor D (CFD) ELISA Kit | CFD elisa kit

Human Complement Factor D (CFD) ELISA Kit

Cat. Num. AAA455969

• Gene Names: CFD; DF; ADN; PFD; ADIPSIN
• Reactivity: Human
• Synonyms: Complement Factor D (CFD); Human Complement Factor D (CFD) ELISA Kit; CF-D; DF; PFD; ADN; Adipsin; Properdin Factor D; C3 convertase activator; CFD elisa kit

• Reactivity: Human
• Sequence Length: 253

• Samples: Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.137ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 955654851
• NCBI GeneID: 1675
• NCBI Accession #: NP_001304264.1
• NCBI GenBank Nucleotide #: NM_001317335.1
• UniProt Accession #: P00746; Q5U5S1; Q86VJ5; Q8N4E0; Q8WZB4; B4DV76
• Molecular Weight: 27,033 Da
• NCBI Official Full Name: complement factor D isoform 2
• NCBI Official Synonym Full Names: complement factor D
• NCBI Official Symbol: CFD
• NCBI Official Synonym Symbols: DF; ADN; PFD; ADIPSIN
• NCBI Protein Information: complement factor D
• UniProt Protein Name: Complement factor D
• Protein Family: Complement factor
• UniProt Gene Name: CFD
• UniProt Synonym Gene Names: DF; PFD

NCBI Description

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]

Uniprot Description

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.