DCAF7 cdna clone

DCAF7

Cat. Num. AAA200615

• Gene Names: DCAF7; AN11; HAN11; WDR68; SWAN-1
• Synonyms: DCAF7; AN11; HAN11; SWAN-1; WDR68; DCAF7 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGTCCCTGC ACGGCAAACG GAAGGAGATC TACAAGTATG AAGCGCCCTG GACAGTCTAC GCGATGAACT GGAGTGTGCG GCCCGATAAG CGCTTTCGCT TGGCGCTGGG CAGCTTCGTG GAGGAGTACA ACAACAAGGT TCAGCTTGTT GGTTTAGATG AGGAGAGTTC AGAGTTTATT TGCAGAAACA CCTTTGACCA CCCATACCCC ACCACAAAGC TCATGTGGAT CCCTGACACA AAAGGCGTCT ATCCAGACCT ACTGGCAACA AGCGGTGACT ATCTCCGTGT GTGGAGGGTT GGTGAAACAG AGACCAGGCT GGAGTGTTTG CTAAACAATA ATAAGAACTC TGATTTCTGT GCTCCCCTGA CCTCCTTTGA CTGGAATGAG GTGGATCCTT ATCTTTTAGG TACCTCAAGC ATTGATACGA CATGCACCAT CTGGGGGCTG GAGACAGGGC AGGTGTTAGG GCGAGTGAAT CTCGTGTCTG GCCACGTGAA GACCCAGCTG ATCGCCCATG ACAAAGAGGT CTATGATATT GCATTTAGCC GGGCCGGGGG TGGCAGGGAC ATGTTTGCCT CTGTGGGTGC TGATGGCTCG GTGCGGATGT TTGACCTCCG CCATCTAGAA CACAGCACCA TCATTTACGA AGACCCACAG CATCACCCAC TGCTTCGCCT CTGCTGGAAC AAGCAGGACC CTAACTACCT GGCCACCATG GCCATGGATG GAATGGAGGT GGTGATTCTA GATGTCCGGG TTCCCTGCAC ACCTGTCGCC AGGTTAAACA ACCATCGAGC ATGTGTCAAT GGCATTGCTT GGGCCCCACA TTCATCCTGC CACATCTGCA CTGCAGCGGA TGACCACCAG GCTCTCATCT GGGACATCCA GCAAATGCCC CGAGCCATTG AGGACCCTAT CCTGGCCTAC ACAGCTGAAG GAGAGATCAA CAATGTGCAG TGGGCATCAA CTCAGCCCGA CTGGATCGCC ATCTGCTACA ACAACTGCCT GGAGATACTC AGAGTGTAG; ; Translation Sequence: MSLHGKRKEI YKYEAPWTVY AMNWSVRPDK RFRLALGSFV EEYNNKVQLV GLDEESSEFI CRNTFDHPYP TTKLMWIPDT KGVYPDLLAT SGDYLRVWRV GETETRLECL LNNNKNSDFC APLTSFDWNE VDPYLLGTSS IDTTCTIWGL ETGQVLGRVN LVSGHVKTQL IAHDKEVYDI AFSRAGGGRD MFASVGADGS VRMFDLRHLE HSTIIYEDPQ HHPLLRLCWN KQDPNYLATM AMDGMEVVIL DVRVPCTPVA RLNNHRACVN GIAWAPHSSC HICTAADDHQ ALIWDIQQMP RAIEDPILAY TAEGEINNVQ WASTQPDWIA ICYNNCLEIL RV
• Sequence Length: 342

• Species: Human
• Chromosome Location: 17q23.3
• OMIM Reference Number: 605973
• cDNA Size: 1029bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted Nde I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for DCAF7 cdna clone

DCAF7, also known as DDB1-and CuL4-associated factor, involved in craniofacial development. This protein acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. This protein associates with DIAPH1 and controls GLI1 transcriptional activity. This protein could be involved in normal and disease skin development.

Product Categories/Family for DCAF7 cdna clone

Development

NCBI and Uniprot Product Information

• NCBI GI #: 108936958
• NCBI GeneID: 10238
• NCBI Accession #: NP_005819.3
• NCBI GenBank Nucleotide #: NM_005828.4
• UniProt Accession #: P61962
• NCBI Official Full Name: DDB1- and CUL4-associated factor 7
• NCBI Official Synonym Full Names: DDB1 and CUL4 associated factor 7
• NCBI Official Symbol: DCAF7
• NCBI Official Synonym Symbols: AN11; HAN11; WDR68; SWAN-1
• NCBI Protein Information: DDB1- and CUL4-associated factor 7
• UniProt Protein Name: DDB1- and CUL4-associated factor 7
• Protein Family: DDB1- and CUL4-associated factor
• UniProt Gene Name: DCAF7
• UniProt Synonym Gene Names: HAN11; WDR68
• UniProt Entry Name: DCAF7_HUMAN

NCBI Description

This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Description

WDR68: a WD40 repeat protein. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: nucleoplasm; nuclear matrix; protein complex; cytoplasm

Molecular Function: protein binding

Biological Process: multicellular organismal development; protein ubiquitination