ASH2L cdna clone
ASH2L cDNA Clone
NCBI and Uniprot Product Information
Uniprot Description
ASH2L: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with DPY30 and RBBP5; the interaction is direct. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A and SETD1B. Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; Transcription regulation
Chromosomal Location of Human Ortholog: 8p11.2
Cellular Component: histone methyltransferase complex; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; DNA binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding
Biological Process: histone H3-K4 methylation; positive regulation of cell proliferation; response to DNA damage stimulus; response to estrogen stimulus; transcription from RNA polymerase II promoter
Research Articles on ASH2L
Similar Products
Product Notes
The ASH2L ash2l (Catalog #AAA1270083) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatactc aggcgggctc cgtggatgaa gagaatggcc gacagttggg tgaggtagag ctgcaatgtg ggatttgtac aaaatggttc acggctgaca catttggcat agatacctca tcctgtctac ctttcatgac caactacagt tttcattgca acgtctgcca tcacagtggg aatacctatt tcctccggaa gcaagcaaac ttgaaggaaa tgtgccttag tgctttggcc aacctgacat ggcagtcccg aacacaggat gaacatccga agacaatgtt ctccaaagat aaggatatta taccatttat tgataaatac tgggagtgca tgacaaccag acagagacct gggaaaatga cttggccaaa taacattgtt aaaacaatga gtaaagaaag agatgtattc ttggtaaagg aacacccaga tccaggcagt aaagatccag aagaagatta ccccaaattt ggacttttgg atcaggacct tagtaacatt ggtcctgctt atgacaacca aaaacagagc agtgctgtgt ctactagtgg gaatttaaat gggggaattg cagcaggaag cagcggaaaa ggacgaggag ccaagcgcaa acagcaggat ggagggacca cagggaccac caagaaggcc cggagtgacc ctttgttttc tgctcagcgc cttccccctc atggctaccc attggaacac ccgtttaaca aagatggcta tcggtatatt ctagctgagc ctgatccgca cgcccctgac cccgagaagc tggaacttga ctgctgggca ggaaaaccta ttcctggaga cctctacaga gcctgcttgt atgaacgggt tttgttagcc ctacatgatc gagctcccca gttaaagatc tcagatgacc ggctgactgt ggttggagag aagggctact ctatggtgag ggcctctcat ggagtacgga agggtgcctg gtattttgaa atcactgtgg atgagatgcc accagatacc gctgccagac tgggttggtc ccagccccta ggaaaccttc aagctccttt aggttatgat aaatttagct attcttggcg gagcaaaaag ggaaccaagt tccaccagtc cattggcaaa cactactctt ctggctatgg acagggagac gtcctgggat tttatattaa tcttcctgaa gacacagaga cagccaagtc attgccagac acatacaaag ataaggcttt gataaaattc aagagttatt tgtattttga ggaaaaagac tttgtggata aagcagagaa gagcctgaag cagactcccc atagtgagat aatattttat aaaaatggtg tcaatcaagg tgtggcttac aaagatattt ttgagggggt ttacttccca gccatctcac tgtacaagag ctgcacggtt tccattaact ttggaccatg cttcaagtat cctccgaagg atctcactta ccgccctatg agtgacatgg gctggggcgc cgtggtagag cacaccctgg ctgacgtctt gtatcacgtg gagacagaag tggatgggag gcgcagtccc ccatgggaac cctga. It is sometimes possible for the material contained within the vial of "ASH2L, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
