ARAF cdna clone
ARAF cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Uniprot Description
ARAF: a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.
Protein type: Kinase, protein; EC 2.7.11.1; Oncoprotein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; RAF family
Chromosomal Location of Human Ortholog: Xp11.4-p11.2
Cellular Component: cytosol
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: MAPKKK cascade; negative regulation of apoptosis; positive regulation of peptidyl-serine phosphorylation; protein modification process; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway
Research Articles on ARAF
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Product Notes
The ARAF araf (Catalog #AAA1278352) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagccac cacggggccc ccctgccaat ggggccgagc catcccgggc agtgggcacc gtcaaagtat acctgcccaa caagcaacgc acggtggtga ctgtccggga tggcatgagt gtctacgact ctctagacaa ggccctgaag gtgcggggtc taaatcagga ctgctgtgtg gtctaccgac tcatcaaggg acgaaagacg gtcactgcct gggacacagc cattgctccc ctggatggcg aggagctcat tgtcgaggtc cttgaagatg tcccgctgac catgcacaat tttgtacgga agaccttctt cagcctggcg ttctgtgact tctgccttaa gtttctgttc catggcttcc gttgccaaac ctgtggctac aagttccacc agcattgttc ctccaaggtc cccacagtct gtgttgacat gagtaccaac cgccaacagc cctcaaggtt ctaccacagt gtccaggatt tgtccggagg ctccagacag catgaggctc cctcgaaccg ccccctgaat gagttgctaa ccccccaggg tcccagcccc cgcacccagc actgtgaccc ggagcacttc cccttccctg ccccagccaa tgccccccta cagcgcatcc gctccacgtc cactcccaac gtccatatgg tcagcaccac ggcccccatg gactccaacc tcatccagct cactggccag agtttcagca ctgatgctgc cggtagtaga ggaggtagtg atggaacccc ccgggggagc cccagcccag ccagcgtgtc ctcggggagg aagtccccac attccaagtc accagcagag cagcgcgagc ggaagtcctt ggccgatgac aagaagaaag tgaagaacct ggggtaccgg gactcaggct attactggga ggtaccaccc agtgaggtgc agctgctgaa gaggatcggg acgggctcgt ttggcaccgt gtttcgaggg cggtggcatg gcgatgtggc cgtgaaggtg ctcaaggtgt cccagcccac agctgagcag gcccaggctt tcaagaatga gatgcaggtg ctcaggaaga cgcgacatgt caacatcttg ctgtttatgg gcttcatgac ccggccggga tttgccatca tcacacagtg gtgtgagggc tccagcctct accatcacct gcatgtggcc gacacacgct tcgacatggt ccagctcatc gacgtggccc ggcagactgc ccagggcatg gactacctcc atgccaagaa catcatccac cgagatctca agtctaacaa catcttccta catgaggggc tcacggtgaa gatcggtgac tttggcttgg ccacagtgaa gactcgatgg agcggggccc agcccttgga gcagccctca ggatctgtgc tgtggatggc agctgaggtg atccgtatgc aggacccgaa cccctacagc ttccagtcag acgtctatgc ctacggggtt gtgctctacg agcttatgac tggctcactg ccttacagcc acattggctg ccgtgaccag attatcttta tggtgggccg tggctatctg tccccggacc tcagcaaaat ctccagcaac tgccccaagg ccatgcggcg cctgctgtct gactgcctca agttccagcg ggaggagcgg cccctcttcc cccagatcct ggccacaatt gagctgctgc aacggtcact ccccaagatt gagcggagtg cctcggaacc ctccttgcac cgcacccagg ccgatgagtt gcctgcctgc ctactcagcg cagcccgcct tgtgccttag. It is sometimes possible for the material contained within the vial of "ARAF, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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