ARAF cdna clone
ARAF cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Uniprot Description
ARAF: a tyrosine kinase-like kinase of the RAF family. Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Frequently mutated in thyroid cancers, skin melanomas and at lower frequency in a wide range of human cancers. An activating mutation, mimicking phosphorylation of the activation loop, is seen in 60% of malignant melanoma samples. Raf mutations are generally exclusive to Ras activating mutations. Activating mutations are also seen in ~10% of colorectal cancers, in lung cancers and gliomas, and at a lower rate in several other tumors. Inactivating mutations are also seen and may result in activation of c-Raf and Erk. Mutations in B-Raf, MEK1 and MEK2 also associated with cardiofaciocutaneous syndrome, displaying morphological, cardiac and mental defects. Approved Inhibitor: Nexavar/Sorafenib.
Protein type: Protein kinase, Ser/Thr (non-receptor); Oncoprotein; EC 2.7.11.1; Kinase, protein; Protein kinase, TKL; TKL group; RAF family
Chromosomal Location of Human Ortholog: Xp11.4-p11.2
Cellular Component: cytosol
Molecular Function: protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: MAPKKK cascade; negative regulation of apoptosis; positive regulation of peptidyl-serine phosphorylation; protein modification process; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway
Research Articles on ARAF
Similar Products
Product Notes
The ARAF araf (Catalog #AAA1265736) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggagccac cacggggccc ccctgccaat ggggccgagc catcccgggc agtgggcacc gtcaaagtat acctgcccaa caagcaacgc acggtggtga ctgtccggga tggcatgagt gtctacgact ctctagacaa ggccctgaag gtgcggggtc taaatcagga ctgctgtgtg gtctaccgac tcatcaaggg acgaaagacg gtcactgcct gggacacagc cattgctccc ctggatggcg aggagctcat tgtcgaggtc cttgaagatg tcccgctgac catgcacaat tttgtacgga agaccttctt cagcctggcg ttctgtgact tctgccttaa gtttctgttc catggcttcc gttgccaaac ctgtggctac aagttccacc agcattgttc ctccaaggtc cccacagtct gtgttgacat gagtaccaac cgccaacagt tctaccacag tgtccaggat ttgtccggag gctccagaca gcatgaggct ccctcgaacc gccccctgaa tgagttgcta accccccagg gtcccagccc ccgcacccag cactgtgacc cggagcactt ccccttccct gccccagcca atgcccccct acagcgcatc cgctccacgt ccactcccaa cgtccatatg gtcagcacca cggcccccat ggactccaac ctcatccagc tcactggcca gagtttcagc actgatgctg ccggtagtag aggaggtagt gatggaaccc cccgggggag ccccagccca gccagcgtgt cctcggggag gaagtcccca cattccaagt caccagcaga gcagcgcgag cggaagtcct tggccgatga caagaagaaa gtgaagaacc tggggtaccg ggactcaggc tattactggg aggtaccacc cagtgaggtg cagctgctga agaggatcgg gacgggctcg tttggcaccg tgtttcgagg gcggtggcat ggcgatgtgg ccgtgaaggt gctcaaggtg tcccagccca cagctgagca ggcccaggct ttcaagaatg agatgcaggt gctcaggaag acgcgacatg tcaacatctt gctgtttatg ggcttcatga cccggccggg atttgccatc atcacacagt ggtgtgaggg ctccagcctc taccatcacc tgcatgtggc cgacacacgc ttcgacatgg tccagctcat cgacgtggcc cggcagactg cccagggcat ggactacctc catgccaaga acatcatcca ccgagatctc aagtctaaca acatcttcct acatgagggg ctcacggtga agatcggtga ctttggcttg gccacagtga agactcgatg gagcggggcc cagcccttgg agcagccctc aggatctgtg ctgtggatgg cagctgaggt gatccgtatg caggacccga acccctacag cttccagtca gacgtctatg cctacggggt tgtgctctac gagcttatga ctggctcact gccttacagc cacattggct gccgtgacca gattatcttt atggtgggcc gtggctatct gtccccggac ctcagcaaaa tctccagcaa ctgccccaag gccatgcggc gcctgctgtc tgactgcctc aagttccagc gggaggagcg gcccctcttc ccccagatcc tggccacaat tgagctgctg caacggtcac tccccaagat tgagcggagt gcctcggaac cctccttgca ccgcacccag gccgatgagt tgcctgcctg cctactcagc gcagcccgcc ttgtgcctta g. It is sometimes possible for the material contained within the vial of "ARAF, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
