ALKBH3 cdna clone
ALKBH3 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Uniprot Description
ALKBH3: Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-; DNA repair, damage; Oxidoreductase; Hydrolase; Demethylase
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: cytoplasm; mitochondrion; nucleoplasm; nucleus
Molecular Function: DNA-N1-methyladenine dioxygenase activity; ferrous iron binding; protein binding
Biological Process: cell proliferation; DNA dealkylation; DNA repair
Research Articles on ALKBH3
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Product Notes
The ALKBH3 alkbh3 (Catalog #AAA1276401) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGAGGAAA AAAGACGGCG AGCCCGAGTT CAGGGAGCCT GGGCTGCCCC TGTTAAAAGC CAGGCCATTG CTCAGCCAGC TACCACTGCT AAGAGCCATC TCCACCAGAA GCCTGGCCAG ACCTGGAAGA ACAAAGAGCA TCATCTCTCT GACAGAGAGT TTGTGTTCAA AGAACCTCAG CAGGTAGTAC GTAGAGCTCC TGAGCCACGA GTGATTGACA GAGAGGGTGT GTATGAAATC AGCCTGTCAC CCACAGGTGT ATCTAGGGTC TGTTTGTATC CTGGCTTTGT TGACGTGAAA GAAGCTGACT GGATATTGGA ACAGCTTTGT CAAGATGTTC CCTGGAAACA GAGGACCGGC ATCAGAGAGG ATATAACTTA TCAGCAACCA AGACTTACAG CATGGTATGG AGAACTTCCT TACACTTATT CAAGAATCAC TATGGAACCA AATCCTCACT GGCACCCTGT GCTGCGCACA CTAAAGAACC GCATTGAAGA GAACACTGGC CACACCTTCA ACTCCTTACT CTGCAATCTT TATCGCAATG AGAAGGACAG CGTGGACTGG CACAGTGATG ATGAACCCTC ACTAGGGAGG TGCCCCATTA TTGCTTCACT AAGTTTTGGT GCCACACGCA CATTTGAGAT GAGAAAGAAG CCACCACCAG AAGAGAATGG AGAGTACACA TATGTGGAAA GAGTGAAGAT ACCCTTGGAT CATGGGACCT TGTTAATCAT GGAAGGAGCG ACACAAGCTG ACTGGCAGCA TCGAGTGCCC AAAGAATACC ACTCTAGAGA ACCGAGAGTG AACCTGACCT TTCGGACAGT CTATCCAGAC CCTCGAGGGG CACCCTGGTG A. It is sometimes possible for the material contained within the vial of "ALKBH3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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