ADAM8 cdna clone
ADAM8 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
Uniprot Description
ADAM8: Possible involvement in extravasation of leukocytes.
Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: cell surface; cytoplasm; dense core granule membrane; integral to plasma membrane; plasma membrane; podosome; specific granule
Molecular Function: calcium ion binding; cell adhesion molecule binding; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding
Biological Process: activation of NF-kappaB transcription factor; angiogenesis; cell morphogenesis; extracellular matrix disassembly; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of protein secretion; positive regulation of T cell differentiation in the thymus; regulation of cell-cell adhesion
Research Articles on ADAM8
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Product Notes
The ADAM8 adam8 (Catalog #AAA1273456) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGCGCGGCC TCGGGCTCTG GCTGCTGGGC GCGATGATGC TGCCTGCGAT TGCCCCCAGC CGGCCCTGGG CCCTCATGGA GCAGTATGAG GTCGTGTTGC CGCGGCGTCT GCCAGGCCCC CGAGTCCGCC GAGCTCTGCC CTCCCACTTG GGCCTGCACC CAGAGAGGGT GAGCTACGTC CTTGGGGCCA CAGGGCACAA CTTCACCCTC CACCTGCGGA AGAACAGGGA CCTGCTGGGT TCCGGCTACA CAGAGACCTA TACGGCTGCC AATGGCTCCG AGGTGACGGA GCAGCCTCGC GGGCAGGACC ACTGCTTCTA CCAGGGCCAC GTAGAGGGGT ACCCGGACTC AGCCGCCAGC CTCAGCACCT GTGCCGGCCT CAGGGGTTTC TTCCAGGTGG GGTCAGACCT GCACCTGATC GAGCCCCTGG ATGAAGGTGG CGAGGGCGGA CGGCACGCCG TGTACCAGGC TGAGCACCTG CTGCAGACGG CCGGGACCTG CGGGGTCAGC GACGACAGCC TGGGCAGCCT CCTGGGACCC CGGACGGCAG CCGTCTTCAG GCCTCGGCCC GGGGACTCTC TGCCATCCCG AGAGACCCGC TACGTGGAGC TGTATGTGGT CGTGGACAAT GCAGAGTTCC AGATGCTGGG GAGCGAAGCA GCCGTGCGTC ATCGGGTGCT GGAGGTGGTG AATCACGTGG ACAAGCTATA TCAGAAACTC AACTTCCGTG TGGTCCTGGT GGGCCTGGAG ATTTGGAATA GTCAGGACAG GTTCCACGTC AGCCCCGACC CCAGTGTCAC ACTGGAGAAC CTCCTGACCT GGCAGGCACG GCAACGGACA CGGCGGCACC TGCATGACAA CGTACAGCTC ATCACGGGTG TCGACTTCAC CGGGACTACT GTGGGGTTTG CCAGGGTGTC CGCCATGTGC TCCCACAGCT CAGGGGCTGT GAACCAGGAC CACAGCAAGA ACCCCGTGGG CGTGGCCTGC ACCATGGCCC ATGAGATGGG CCACAACCTG GGCATGGACC ATGATGAGAA CGTCCAGGGC TGCCGCTGCC AGGAACGCTT CGAGGCCGGC CGCTGCATCA TGGCAGGCAG CATTGGCTCC AGTTTCCCCA GGATGTTCAG TGACTGCAGC CAGGCCTACC TGGAGAGCTT TTTGGAGCGG CCGCAGTCGG TGTGCCTCGC CAACGCCCCT GACCTCAGCC ACCTGGTGGG CGGCCCCGTG TGTGGGAACC TGTTTGTGGA GCGTGGGGAG CAGTGCGACT GCGGCCCCCC CGAGGACTGC CGGAACCGCT GCTGCAACTC TACCACCTGC CAGCTGGCTG AGGGGGCCCA GTGTGCGCAC GGTACCTGCT GCCAGGAGTG CAAGGTGAAG CCGGCTGGTG AGCTGTGCCG TCCCAAGAAG GACATGTGTG ACCTCGAGGA GTTCTGTGAC GGCCGGCACC CTGAGTGCCC GGAAGACGCC TTCCAGGAGA ACGGCACGCC CTGCTCCGGG GGCTACTGCT ACAACGGGGC CTGTCCCACA CTGGCCCAGC AGTGCCAGGC CTTCTGGGGG CCAGGTGGGC AGGCTGCCGA GGAGTCCTGC TTCTCCTATG ACATCCTACC AGGCTGCAAG GCCAGCCGGT ACAGGGCTGA CATGTGTGGC GTTCTGCAGT GCAAGGGTGG GCAGCAGCCC CTGGGGCGTG CCATCTGCAT CGTGGATGTG TGCCACGCGC TCACCACAGA GGATGGCACT GCGTATGAAC CAGTGCCCGA GGGCACCCGG TGTGGACCAG AGAAGGTTTG CTGGAAAGGA CGTTGCCAGG ACTTACACGT TTACAGATCC AGCAACTGCT CTGCCCAGTG CCACAACCAT GGGGTGTGCA ACCACAAGCA GGAGTGCCAC TGCCACGCGG GCTGGGCCCC GCCCCACTGC GCGAAGCTGC TGACTGAGGT GCACGCAGCG TCCGGGAGCC TCCCCGTCCT CGTGGTGGTG GTTCTGGTGC TCCTGGCAGT TGTGCTGGTC ACCCTGGCAG GCATCATCGT CTACCGCAAA GCCCGGAGCC GCATCCTGAG CAGGAACGTG GCTCCCAAGA CCACAATGGG GCGCTCCAAC CCCCTGTTCC ACCAGGCTGC CAGCCGCGTG CCGGCCAAGG GCGGGGCTCC AGCCCCATCC AGGGGCCCCC AAGAGCTGGT CCCCACCACC CACCCGGGCC AGCCCGCCCG ACACCCGGCC TCCTCGGTGG CTCTGAAGAG GCCGCCCCCT GCTCCTCCGG TCACTGTGTC CAGCCCACCC TTCCCAGTTC CTGTCTACAC CCGGCAGGCA CCAAAGCAGG TCATCAAGCC AACGTTCGCA CCCCCAGTGC CCCCAGTCAA ACCCGGGGCT GGTGCGGCCA ACCCTGGTCC AGCTGAGGGT GCTGTTGGCC CAAAGGTTGC CCTGAAGCCC CCCATCCAGA GGAAGCAAGG AGCCGGAGCT CCCACAGCAC CCTAG. It is sometimes possible for the material contained within the vial of "ADAM8, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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