CCRK Blocking Peptide | CDK20 blocking peptide

CCRK Antibody (N-term) Blocking Peptide

• Gene Names: CDK20; P42; CCRK; CDCH; PNQALRE
• Synonyms: CCRK; CCRK Antibody (N-term) Blocking Peptide; Cyclin-dependent kinase 20; CDK-activating kinase p42; CAK-kinase p42; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent protein kinase H; Cyclin-kinase-activating kinase p42; CDK20; CDCH; CDK20 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CCRK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 346

• Cellular Location: Nucleus. Cytoplasm. Cell projection, cilium
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CDK20 blocking peptide

Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.

NCBI and Uniprot Product Information

• NCBI GI #: 74759739
• NCBI GeneID: 23552
• UniProt Accession #: Q8IZL9; O95137; Q5EDC4; Q5VYW1; Q9BUF4; A2A389; A2A390; B4DQX1
• Molecular Weight: 36,113 Da
• NCBI Official Full Name: Cyclin-dependent kinase 20
• NCBI Official Synonym Full Names: cyclin dependent kinase 20
• NCBI Official Symbol: CDK20
• NCBI Official Synonym Symbols: P42; CCRK; CDCH; PNQALRE
• NCBI Protein Information: cyclin-dependent kinase 20
• UniProt Protein Name: Cyclin-dependent kinase 20
• Protein Family: Cyclin-dependent kinase
• UniProt Gene Name: CDK20
• UniProt Synonym Gene Names: CCRK; CDCH; CAK-kinase p42
• UniProt Entry Name: CDK20_HUMAN

NCBI Description

The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]

Uniprot Description

CDK20: cyclin-dependent protein kinase H. A CMGC kinase of the CDK family. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Protein type: Protein kinase, CMGC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; EC 2.7.11.22; CMGC group; CDK family; CDK/CCRK subfamily; CCRK subfamily

Chromosomal Location of Human Ortholog: 9q22.1

Molecular Function: protein binding