Typical Testing Data/Standard Curve
Human CD325 ELISA Kit | CDH2 elisa kit
Human CD325 ELISA Kit
Typical Testing Data/Standard Curve
Typical Testing Data/Standard Curve
Background/Introduction: Cadherin-2 (CDH2), also known as neural cadherin(NCAD), is a protein that in humans is encoded by the CDH2 gene. It is a classical cadherin from the cadherin superfamily. This gene is mapped to 18q12.1. Cadherin-2 is expressed in the brain, skeletal and cardiac muscle. Cadherin-2 is commonly found in cancer cells and provides a mechanism for transendothelial migration. It is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone. [provided by RefSeq, Nov 2015]
Uniprot Description
CDH2: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. Interacts with CDCP1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: apical plasma membrane; basolateral plasma membrane; catenin complex; cell-cell adherens junction; cortical actin cytoskeleton; cytoplasm; fascia adherens; focal adhesion; integral to membrane; intercellular junction; lamellipodium; plasma membrane; synapse
Molecular Function: alpha-catenin binding; beta-catenin binding; calcium ion binding; gamma-catenin binding; nitric-oxide synthase binding; protein binding; protein complex binding; protein kinase binding; protein phosphatase binding
Biological Process: blood vessel morphogenesis; brain morphogenesis; calcium-dependent cell-cell adhesion; cell adhesion; cell migration; cerebral cortex development; glial cell differentiation; heterophilic cell adhesion; homeostasis of number of cells; homophilic cell adhesion; intercellular junction assembly and maintenance; muscle cell differentiation; positive regulation of MAPKKK cascade; positive regulation of muscle cell differentiation; protein heterooligomerization; radial glial cell differentiation; regulation of axonogenesis; regulation of myelination; regulation of Rho protein signal transduction; striated muscle cell differentiation
Research Articles on CDH2
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Product Notes
The Human CDH2 cdh2 (Catalog #AAA8244712) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA8244712 ELISA Kit recognizes Human CDH2. AAA Biotech's CD325 can be used in a range of immunoassay formats including, but not limited to, Sandwich ELISA (EIA). Researchers should empirically determine the suitability of the CDH2 cdh2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD325, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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