CD93 recombinant protein

CD93, 22-580aa, Human, His-tag, Baculovirus

Cat. Num. AAA206401

• Gene Names: CD93; C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: CD93; 22-580aa; Human; His-tag; Baculovirus; Complement component C1q receptor; C1qR (P); C1QR1; C1qRP; CDw93; dJ737E23.1; ECSM3; MXRA4; C1q receptor 1 C1q/MBL/SPA receptor; C1qR; C1qR (p); C1qr1 C1QR1_HUMAN; C1qRp; CD93 antigen CD93 molecule; Complement component 1 q subcomponent receptor 1; Matrix remodeling associated protein 4; Matrix remodelling associated 4 Matrix-remodeling-associated protein 4; CD93 recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: TGADTEAVVC VGTACYTAHS GKLSAAEAQN HCNQNGGNLA TVKSKEEAQH VQRVLAQLLR REAALTARMS KFWIGLQREK GKCLDPSLPL KGFSWVGGGE DTPYSNWHKE LRNSCISKRC VSLLLDLSQP LLPSRLPKWS EGPCGSPGSP GSNIEGFVCK FSFKGMCRPL ALGGPGQVTY TTPFQTTSSS LEAVPFASAA NVACGEGDKD ETQSHYFLCK EKAPDVFDWG SSGPLCVSPK YGCNFNNGGC HQDCFEGGDG SFLCGCRPGF RLLDDLVTCA SRNPCSSSPC RGGATCVLGP HGKNYTCRCP QGYQLDSSQL DCVDVDECQD SPCAQECVNT PGGFRCECWV GYEPGGPGEG ACQDVDECAL GRSPCAQGCT NTDGSFHCSC EEGYVLAGED GTQCQDVDEC VGPGGPLCDS LCFNTQGSFH CGCLPGWVLA PNGVSCTMGP VSLGPPSGPP DEEDKGEKEG STVPRAATAS PTRGPEGTPK ATPTTSRPSL SSDAPITSAP LKMLAPSGSP GVWREPSIHH ATAASGPQEP AGGDSSVATQ NNDGTDGQKV EHHHHHH
• Sequence Length: 652

• Applicable Applications for CD93 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for CD93 recombinant protein

CD93, also known as complement component C1q receptor, belongs to a family of transmembrane glycoproteins which also includes endosialin and thrombomodulin. It is involved in various aspects of inflammatory reactions. CD93 is expressed by vascular endothelial cells and by a variety of hematopoietic cells. It is receptor for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). Recombinant human CD93, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for CD93 recombinant protein

Immunology; Adhesion & Movement

References

McGreal EP., et al. (2002) J Immunol. 168:5222-5232.; Chevrier S., et al. (2009) Proc Natl Acad Sci USA. 106:3895-3900.;

NCBI and Uniprot Product Information

• NCBI GI #: 88758613
• NCBI GeneID: 22918
• NCBI Accession #: NP_036204
• NCBI GenBank Nucleotide #: NM_012072.3
• UniProt Accession #: Q9NPY3; O00274
• Molecular Weight: 59.3kDa (567aa) 70-100KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: complement component C1q receptor
• NCBI Official Synonym Full Names: CD93 molecule
• NCBI Official Symbol: CD93
• NCBI Official Synonym Symbols: C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
• NCBI Protein Information: complement component C1q receptor
• UniProt Protein Name: Complement component C1q receptor
• Protein Family: Complement component C1q receptor
• UniProt Gene Name: CD93
• UniProt Synonym Gene Names: C1QR1; MXRA4; C1qR; C1qR(p); C1qRp

NCBI Description

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.