CD7/GP40/TP41 Recombinant Protein | CD7 recombinant protein

Recombinant Human CD7/GP40/TP41 Protein (C-Fc)

Cat. Num. AAA2557121

• Gene Names: CD7; GP40; TP41; Tp40; LEU-9
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: CD7/GP40/TP41; Recombinant Human CD7/GP40/TP41 Protein (C-Fc); T-Cell Antigen CD7; GP40; T-Cell Leukemia Antigen; T-Cell Surface Antigen Leu-9; TP41; CD7; CD7 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Ala26-Pro180
• Sequence Length: 240

• Species: Human
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CD7 recombinant protein

Protein Construction: Recombinant Human CD7 is produced by our mammalian expression system and the target gene encoding Ala26-Pro180 is expressed with a Fc tag at the C-terminus.

Background: T-Cell Antigen CD7 is a single-pass type I membrane protein that that belongs to the the immunoglobulin superfamily. Human CD7 is synthesized as a 240 amino acid precursor that contains a 25 amino acid signal sequence and a 215 amino acid mature chain with a Ig-like (immunoglobulin-like) domain. CD7 is normally expressed on all T-lymphocytes, NK-cells, pre-B lymphocytes and pleuripotent hematopoietic stem cells. CD7 plays an essential role in T-cell interactions, T-cell/B-cell interaction during early lymphoid development, T- and NK-cell activation and cytokine production. CD7 has been shown to interact with PIK3R1and SECTM1. However, the function of the CD7 protein in the immune system is still largely unknown.

NCBI and Uniprot Product Information

• NCBI GI #: 5453613
• NCBI GeneID: 924
• NCBI Accession #: NP_006128.1
• NCBI GenBank Nucleotide #: NP_006128.1
• UniProt Accession #: P09564
• Molecular Weight: Molecular Mass: 43.4kDa; Actual Protein Molecular Mass: 59kDa
• NCBI Official Full Name: T-cell antigen CD7
• NCBI Official Synonym Full Names: CD7 molecule
• NCBI Official Symbol: CD7
• NCBI Official Synonym Symbols: GP40; TP41; Tp40; LEU-9
• NCBI Protein Information: T-cell antigen CD7
• UniProt Protein Name: T-cell antigen CD7
• Protein Family: T-cell antigen
• UniProt Gene Name: CD7
• UniProt Entry Name: CD7_HUMAN

NCBI Description

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]

Uniprot Description

CD7: Not yet known.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 17q25.2-q25.3

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: receptor activity

Biological Process: T cell activation; homeostasis of number of cells within a tissue; immune response; transmembrane receptor protein tyrosine kinase signaling pathway