SDS-PAGE
Macrosialin Recombinant Protein | Cd68 recombinant protein
Recombinant Mouse Macrosialin
Gene Names
Cd68; Lamp4; gp110; Scard1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Macrosialin; Recombinant Mouse Macrosialin; CD68; Cd68 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
21-291. Partial, provide the complete extracellular domain.
Sequence
DCPHKKAVTLLPSFTMTPTATESTASPTTSHRPTTTSHGNVTVHTSSGPTTVTHNPATTTSHGNATISHATVSPTTNGTATSPRSSTVGPHPGPPPPSPSPRSKGALGNYTWANGSQPCVQLQAQIQIRILYPIQGGRKAWGISVLNPNKTKVQGGCDGTHPHLSLSFPYGQLTFGFKQDLHQSPSTVYLDYMAVEYNVSFPQAAQWTFMAQNSSLRELQAPLGQSFCCGNASIVLSPAVHLDLLSLRLQAAQLPDKGHFGPCFSCNRDQS
Sequence Length
291
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
SDS-PAGE
SDS-PAGE
Related Product Information for Cd68 recombinant protein
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
References
Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family.Holness C.L., da Silva R.P., Fawcett J., Gordon S., Simmons D.L.J. Biol. Chem. 268:9661-9666(1993)
Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein.Jiang Z., Shih D.M., Xia Y.R., Lusis A.J., de Beer F.C., de Villiers W.J.S., van der Westhuyzen D.R., de Beer M.C.Genomics 50:199-205(1998)
Functional comparison of the murine macrosialin and human CD68 promoters in macrophage and nonmacrophage cell lines.Greaves D.R., Quinn C.M., Seldin M.F., Gordon S.Genomics 54:165-168(1998)
The macrosialin promoter directs high levels of transcriptional activity in macrophages dependent on combinatorial interactions between PU.1 and c-Jun.Li A.C., Guidez F.R.B., Collier J.G., Glass C.K.J. Biol. Chem. 273:5389-5399(1998)
Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11.Miyashita A., Shimizu N., Endo N., Hanyuu T., Ishii N., Ito K., Itoh Y., Shirai M., Nakajima T., Odani S., Kuwano R.Gene 237:53-60(1999)
Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009)
Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice.Denny C.A., Kasperzyk J.L., Gorham K.N., Bronson R.T., Seyfried T.N.J. Neurosci. Res. 83:1028-1038(2006)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
30.8 kDa
NCBI Official Full Name
macrosialin
NCBI Official Synonym Full Names
CD68 antigen
NCBI Official Symbol
Cd68
NCBI Official Synonym Symbols
Lamp4; gp110; Scard1
NCBI Protein Information
macrosialin
UniProt Protein Name
Macrosialin
Protein Family
UniProt Gene Name
Cd68
UniProt Entry Name
CD68_MOUSE
Uniprot Description
CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral
Cellular Component: endosome; integral to membrane; lysosome; membrane; plasma membrane
Research Articles on Cd68
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Product Notes
The Cd68 cd68 (Catalog #AAA960585) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 21-291. Partial, provide the complete extracellular domain. The amino acid sequence is listed below: DCPHKKAVTL LPSFTMTPTA TESTASPTTS HRPTTTSHGN VTVHTSSGPT TVTHNPATTT SHGNATISHA TVSPTTNGTA TSPRSSTVGP HPGPPPPSPS PRSKGALGNY TWANGSQPCV QLQAQIQIRI LYPIQGGRKA WGISVLNPNK TKVQGGCDGT HPHLSLSFPY GQLTFGFKQD LHQSPSTVYL DYMAVEYNVS FPQAAQWTFM AQNSSLRELQ APLGQSFCCG NASIVLSPAV HLDLLSLRLQ AAQLPDKGHF GPCFSCNRDQ S. It is sometimes possible for the material contained within the vial of "Macrosialin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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