Dermatopontin/DPT Recombinant Protein | DPT recombinant protein

Recombinant Mouse Dermatopontin/DPT Protein (C-Fc)

Cat. Num. AAA2557508

• Gene Names: Cd36; FAT; GPIV; Scarb3
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Dermatopontin/DPT; Recombinant Mouse Dermatopontin/DPT Protein (C-Fc); Early quiescence protein 1; EQ-1; Tyrosine-rich acidic matrix protein; TRAMP; DPT recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.
• Sequence: Gln19-Val201
• Sequence Length: 472

• Species: Mouse
• Endotoxin: < 1.0 EU per mug as determined by the LAL method.
• Fusion Tag: C-Fc
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for DPT recombinant protein

Protein Construction: Recombinant Mouse Dermatopontin is produced by our mammalian expression system and the target gene encoding Gln19-Val201 is expressed with a Fc tag at the C-terminus.

Background: Platelet Glycoprotein 4(CD36) is belongs to the class B scavenger receptor family. The molecule CD36 is synthesized as a 472 amino acid (aa) protein that contains a 6 aa N-terminal cytoplasmic domain, a 22 aa N-terminal transmembrane segment, a 420 aa extracellular "loop", a 22 aa C-terminal transmembrane segment, and a 9 aa C-terminal cytoplasmic tail. Both cytoplasmic tails are palmitoylated, with the C-terminal tail involved in oxidized LDL binding. With respect to the extracellular loop, the N-terminal region is believed to bind both thrombospondin-1 and Plasmodium-infected erythrocytes. Other ligands for CD36 include long-chain fatty acids, collagen, phospholipids and apoptotic cells. Cells known to express CD36 include capillary endothelium, adipocytes, skeletal muscle cells, intestinal epithelium, smooth muscle cells and hematopoietic cells such as RBC's, platelets and monocytes. On the surface of cells, CD36 is suggested to exist as a dimer in response to ligation (7). CD36 is reported to regulate fatty uptake, act as an angiogenic with TSP-1, and participate in the clearance of apoptotic phagocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 227116347
• NCBI GeneID: 12491
• NCBI Accession #: NP_001153027.1
• NCBI GenBank Nucleotide #: NP_001153027.1
• UniProt Accession #: Q08857
• Molecular Weight: Molecular Mass: 49.1kDa; Actual Protein Molecular Mass: 58kDa
• NCBI Official Full Name: platelet glycoprotein 4
• NCBI Official Synonym Full Names: CD36 molecule
• NCBI Official Symbol: Cd36
• NCBI Official Synonym Symbols: FAT; GPIV; Scarb3
• NCBI Protein Information: platelet glycoprotein 4
• UniProt Protein Name: Platelet glycoprotein 4
• Protein Family: Dermatopontin
• UniProt Gene Name: Cd36
• UniProt Synonym Gene Names: GPIIIB; GPIV
• UniProt Entry Name: CD36_MOUSE

Uniprot Description

CD36: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7). Belongs to the CD36 family.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: apical part of cell; brush border membrane; caveola; cell surface; endoplasmic reticulum; external side of plasma membrane; extracellular space; Golgi apparatus; intracellular; intracellular membrane-bound organelle; lipid raft; membrane; mitochondrion; plasma membrane; protein complex; sarcolemma

Molecular Function: high-density lipoprotein binding; lipid binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding

Biological Process: apoptotic cell clearance; cell surface receptor linked signal transduction; cGMP-mediated signaling; cholesterol absorption; cholesterol transport; defense response to Gram-positive bacterium; eating behavior; elevation of cytosolic calcium ion concentration; fatty acid metabolic process; fatty acid oxidation; fatty acid transport; glucose homeostasis; interleukin-1 beta secretion; intestinal absorption; lipoprotein transport; long-chain fatty acid metabolic process; long-chain fatty acid transport; low density lipoprotein mediated signaling; negative regulation of angiogenesis; negative regulation of systemic arterial blood pressure; negative regulation of transcription factor import into nucleus; negative regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction; phagocytosis, recognition; positive regulation of blood coagulation; positive regulation of cell-matrix adhesion; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of MAPKKK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of tumor necrosis factor production; receptor internalization; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; response to lipid; response to mechanical stimulus; sensory perception of taste; sequestering of lipid; triacylglycerol metabolic process; triacylglycerol transport