CD28 recombinant protein

Recombinant Human CD28

Cat. Num. AAA147226

• Gene Names: CD28; Tp44
• Purity: Greater than 90.0% as determined by SDS-PAGE
• Synonyms: CD28; Recombinant Human CD28; T-cell-specific surface glycoprotein CD28; TP44; CD_antigen: CD28; T-cell-specific surface glycoprotein CD28 isoform 1; CD28 Human; CD28 Human Recombinant; CD28 recombinant protein

• Host: Sf9, Baculovirus cells
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE
• Form/Format: Sterile filtered colorless solution; Protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol
• Sequence: ADP NKILVKQ SPMLVAYDNA VNLSCKYSYN LFSREFRASL HKGLDSAVEV CVVYGNYSQQ LQVYSKTGFN CDGKLGNESV TFYLQNLYVN QTDIYFCKIE VMYPPPYLDN EKSNGTIIHV KGKHLCPSPL FPGPSKPLEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH.
• Sequence Length: 220

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at-20 degree C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles

Related Product Information for CD28 recombinant protein

Description: CD28 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 376 amino acids (19-152a.a.) and having a molecular mass of 42.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). CD28 is expressed with a 242 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Introduction: CD28 co-stimulation is necessary for CD4 positive T-cell proliferation & survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence.

Product Categories/Family for CD28 recombinant protein

Recombinant & Natural Proteins; CD Antigens; Other; CD28 Human

NCBI and Uniprot Product Information

• NCBI GI #: 115973
• NCBI GeneID: 940
• UniProt Accession #: P10747; Q13964; Q52M23; Q70WG0; Q8NI54; Q8NI55; Q8NI56; Q8WXJ2; Q9BYV0; A8KAC1
• Molecular Weight: 26,186 Da
• NCBI Official Full Name: T-cell-specific surface glycoprotein CD28
• NCBI Official Synonym Full Names: CD28 molecule
• NCBI Official Symbol: CD28
• NCBI Official Synonym Symbols: Tp44
• NCBI Protein Information: T-cell-specific surface glycoprotein CD28
• UniProt Protein Name: T-cell-specific surface glycoprotein CD28
• Protein Family: T-cell-specific surface glycoprotein
• UniProt Gene Name: CD28

NCBI Description

The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).