RELT/TNFRSF19L recombinant protein

Recombinant RELT/TNFRSF19L

Cat. Num. AAA201112

• Gene Names: RELT; AI3C; TRLT; TNFRSF19L
• Applications: SDS-Page
• Purity: >90% by SDS-PAGE
• Synonyms: RELT/TNFRSF19L; Recombinant RELT/TNFRSF19L; Tumor necrosis factor receptor superfamily member 19L; RELT; TNFRSF19L; TRLT; RELT/TNFRSF19L recombinant protein

• Host: Baculovirus
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.
• Concentration: 0.5mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence Positions: 26-162aa
• Sequence: STTLWQCPPG EEPDLDPGQG TLCRPCPPGT FSAAWGSSPC QPHARCSLWR RLEAQVGMAT RDTLCGDCWP GWFGPWGVPR VPCQPCSWAPLGTHGCDEWG RRARRGVEVA AGASSGGETR QPGNGTRAGG PEETAAQVEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH
• Sequence Length: 430

• Applicable Applications for RELT/TNFRSF19L recombinant protein: SDS-PAGE
• Species: Human
• Endotoxin: <1.0 EU per 1ug of protein (determined by LAL method)
• Tag: hIgG-His-Tag
• Predicted N-Terminal: Ser 26
• Preparation and Storage: Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.

SDS-Page

(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain )

Related Product Information for RELT/TNFRSF19L recombinant protein

RELT, also known tumor necrosis factor receptor superfamily member 19L, is one of the the tumor necrosis factor receptor superfamily. It is expressed in hematopoietic tissues and peripheral blood leukocytes. This protein mediates activation of NF-kappa-B and plays a role in T-cell activation. With overexpression of this protein in HEK-293 cells, it induces p38 and JNK signaling and activates apoptosis. And it can also costimulate T-cell proliferation in the presence of CD3 signaling. Recombinant human RELT protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for RELT/TNFRSF19L recombinant protein

Signal Transduction

References

Cusick JK., et al, (2010) Cell Immunol. 261:1-8. Moua P., et al, (2017) Biochem Biophys Res Commun. 491:25-32.

NCBI and Uniprot Product Information

• NCBI GI #: 21361873
• NCBI GeneID: 84957
• NCBI Accession #: NP_116260.2
• NCBI GenBank Nucleotide #: NP_116260.2
• UniProt Accession #: Q969Z4
• Molecular Weight: 41.4kDa (376aa); 40-57KDa (SDS-PAGE under reducing conditions)
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 19L
• NCBI Official Synonym Full Names: RELT TNF receptor
• NCBI Official Symbol: RELT
• NCBI Official Synonym Symbols: AI3C; TRLT; TNFRSF19L
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 19L
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 19L
• UniProt Gene Name: RELT
• UniProt Synonym Gene Names: TNFRSF19L
• UniProt Entry Name: TR19L_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

RELT: Mediates activation of NF-kappa-B. May play a role in T- cell activation. Belongs to the RELT family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: cytoplasm; integral to membrane; plasma membrane