Dog chemokine (C-C motif) receptor 2 ELISA Kit | CCR2 elisa kit
Dog C-C chemokine receptor type 2, CCR2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
mediates leukocyte migration and activation [RGD, Feb 2006]
Uniprot Description
CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Cellular Component: cell soma; perinuclear region of cytoplasm; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol; external side of plasma membrane
Molecular Function: protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; cytokine binding; chemokine binding; C-C chemokine binding
Biological Process: positive regulation of T-helper 1 type immune response; sensory perception of pain; regulation of cell migration; monocyte chemotaxis; positive regulation of MAPKKK cascade; hemopoiesis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; positive regulation of tumor necrosis factor production; humoral immune response; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; negative regulation of angiogenesis; response to hyperoxia; inflammatory response to antigenic stimulus; negative regulation of T-helper 2 type immune response; response to hypoxia; positive regulation of interleukin-2 production; cellular defense response; blood vessel remodeling; immune response; positive regulation of alpha-beta T cell proliferation; negative regulation of eosinophil degranulation; positive regulation of T cell activation; positive regulation of inflammatory response
Research Articles on CCR2
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Product Notes
The Dog CCR2 ccr2 (Catalog #AAA9310912) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9310912 ELISA Kit recognizes Dog CCR2. It is sometimes possible for the material contained within the vial of "chemokine (C-C motif) receptor 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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