Cyclin-A2 (CCNA2) Recombinant Protein | CCNA2 recombinant protein

Recombinant Human Cyclin-A2 (CCNA2)

Cat. Num. AAA958611

• Gene Names: CCNA2; CCN1; CCNA
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Cyclin-A2 (CCNA2); Recombinant Human Cyclin-A2 (CCNA2); CCNA2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-432, Full length protein
• Sequence: MLGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQRPKTRRVAPLKDLPVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIILEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
• Sequence Length: 432

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for CCNA2 recombinant protein

This protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1
S and G2
M transitions.

NCBI and Uniprot Product Information

• NCBI GI #: 4502613
• NCBI GeneID: 890
• NCBI Accession #: NP_001228.1
• NCBI GenBank Nucleotide #: NM_001237.4
• UniProt Accession #: P20248; Q2M3U6; Q4W5P4; Q6LER8; A8K7B6
• Molecular Weight: 48,551 Da
• NCBI Official Full Name: cyclin-A2
• NCBI Official Synonym Full Names: cyclin A2
• NCBI Official Symbol: CCNA2
• NCBI Official Synonym Symbols: CCN1; CCNA
• NCBI Protein Information: cyclin-A2
• UniProt Protein Name: Cyclin-A2
• Protein Family: Cyclin
• UniProt Gene Name: CCNA2
• UniProt Synonym Gene Names: Cyclin-A

NCBI Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]

Uniprot Description

Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.