C-C motif chemokine 9 Recombinant Protein | Ccl9 recombinant protein

Recombinant Mouse C-C motif chemokine 9

Cat. Num. AAA1265436

• Gene Names: Ccl9; CCF18; MRP-2; Scya9; Scya10
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: C-C motif chemokine 9; Recombinant Mouse C-C motif chemokine 9; CCF18; Macrophage inflammatory protein 1-gamma; MIP-1-gamma; Macrophage inflammatory protein-related protein 2; MRP-2; Small-inducible cytokine A9; Ccl9 recombinant protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 22-114. Partial
• Sequence: QITHATETKEVQSSLKAQQGLEIEMFHMGFQDSSDCCLSYNSRIQCSRFIGYFPTSGGCTRPGIIFISKRGFQVCANPSDRRVQRCIERLEQN

• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

SDS-PAGE

Related Product Information for Ccl9 recombinant protein

Monokine with inflammatory, pyrogenic and chokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.

References

MIP-1 gamma molecular cloning, expression, and biological activities of a novel CC chemokine that is constitutively secreted in vivo.Poltorak A.N., Bazzoni F., Smirnova I.I., Alejos E., Thompson P., Luheshi G., Rothwell N., Beutler B.J. Inflamm. 45:207-219(1995) A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors.Youn B.-S., Jang I.-K., Broxmeyer H.E., Cooper S., Jenkins N.A., Gilbert D.J., Copeland N.G., Elick T.A., Fraser M.J. Jr., Kwon B.S.J. Immunol. 155:2661-2667(1995) Molecular cloning and functional characterization of a novel member of the C-C chemokine family.Hara T., Bacon K.B., Cho L.C., Yoshimura A., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Schall T.J., Miyajima A.J. Immunol. 155:5352-5358(1995) Sequence polymorphisms in the chemokines Scya1 (TCA-3) , Scya2 (monocyte chemoattractant protein (MCP) -1) , and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W., Blankenhorn E.P.J. Immunol. 163:2262-2266(1999) Organization of the mouse CC chemokine cluster containing the genes for C10, MRP-2 and RANTES.Nomiyama H. Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Proteolytic activation of alternative CCR1 ligands in inflammation.Berahovich R.D., Miao Z., Wang Y., Premack B., Howard M.C., Schall T.J.J. Immunol. 174:7341-7351(2005)

NCBI and Uniprot Product Information

• NCBI GI #: 6755434
• NCBI GeneID: 20308
• NCBI Accession #: NP_035468.1
• NCBI GenBank Nucleotide #: NM_011338.2
• UniProt Accession #: P51670; Q5QNW2
• Molecular Weight: 14.6 kDa
• NCBI Official Full Name: C-C motif chemokine 9
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 9
• NCBI Official Symbol: Ccl9
• NCBI Official Synonym Symbols: CCF18; MRP-2; Scya9; Scya10
• NCBI Protein Information: C-C motif chemokine 9
• UniProt Protein Name: C-C motif chemokine 9
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl9
• UniProt Synonym Gene Names: Mrp2; Scya10; Scya9; MIP-1-gamma; MRP-2
• UniProt Entry Name: CCL9_MOUSE

Uniprot Description

CCL9: Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors

Protein type: Cytokine

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; negative regulation of myoblast differentiation; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of inflammatory response