Eotaxin-3 (CCL26) Recombinant Protein | Eotaxin-3 recombinant protein

Human Eotaxin-3 (CCL26) Recombinant

Cat. Num. AAA553086

• Purity: >97%, as determined by SDS-PAGE and HPLC
• Synonyms: Eotaxin-3 (CCL26); Human Eotaxin-3 (CCL26) Recombinant; ccl26; eotaxin-3; eotaxin3; ccl-26; mip-4a; mip4a; Eotaxin-3 recombinant protein

• Host: E Coli
• Purity/Purification: >97%, as determined by SDS-PAGE and HPLC
• Form/Format: Recombinant Eotaxin-3 is presented as 0.2um filtered PBS pH 7.5 with %10 glycerol.
• Sequence: MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY EFTSNSCSQR AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL
• Sequence Length: 94

• Domain: IL8
• Host Note: Optimized DNA sequence encoding Human Eotaxin-3 mature chain was expressed in Escherichia Coli.
• Endotoxin: Endotoxin content was assayed using a LAL gel clot method.; Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Molecular Weight Note: Native human Eotaxin-3/CCL26 has a calculated molecular mass of approximately 9 kDa. ; ; Recombinant Eotaxin-3 is a disulfide-linked homodimeric protein consisting of 72 amino acid residue subunits, and migrates as an approximately 9 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
• Preparation and Storage: Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months. ; ; Avoid repeated freeze/thaw cycles.

Related Product Information for Eotaxin-3 recombinant protein

Both eotaxin-2/CCL24 and eotaxin-3/CCL26 are CC chemokines and functional ligands for CC chemokine receptor 3 (CCR3), which is preferentially expressed on eosinophils. Only 34% of the amino acids in eotaxin-2/CCL24 and eotaxin-3/CCL26 are identical, but these two chemokines have a common characteristic feature in terms of chemotaxis for eosinophils via the CCR3.

Product Categories/Family for Eotaxin-3 recombinant protein

Cytokines

References

• lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: cfh, cd209, Eotaxin-3, and mhc2ta .J Rheumatol, Aug 2009; 36: 1590 - 1595.
• Eotaxin-3 is involved in churg–strauss syndrome – a serum marker closely correlating with disease activity .Rheumatology, Jun 2008; 47: 804 - 808.
• dsrna enhances Eotaxin-3 production through interleukin-4 receptor upregulation in airway epithelial cells .Eur. Respir. J., Nov 2005; 26: 795 - 803.
• chronic aeroallergen during infancy enhances Eotaxin-3 expression in airway epithelium and nerves .Am. J. Respir. Cell Mol. Biol., Jul 2005; 33: 1 - 8.
• Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions .Chest, Jun 2005; 127: 2094 - 2100.