Cation channel sperm-associated protein 2 (Catsper2) Recombinant Protein | Catsper2 recombinant protein
Recombinant Mouse Cation channel sperm-associated protein 2 (Catsper2)
NCBI and Uniprot Product Information
Uniprot Description
CATSPER2: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Belongs to the cation channel sperm-associated (TC 1.A.1.19) family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: cell projection; membrane; integral to membrane; plasma membrane; cilium
Molecular Function: voltage-gated calcium channel activity; calcium channel activity; ion channel activity; voltage-gated ion channel activity; calcium activated cation channel activity
Biological Process: sperm motility; fertilization; transport; calcium ion transport; multicellular organismal development; spermatogenesis; ion transport; cell differentiation; transmembrane transport; sperm capacitation
Research Articles on Catsper2
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Product Notes
The Catsper2 catsper2 (Catalog #AAA1033961) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-588. The amino acid sequence is listed below: MAQEQGHFQL LRADAIRSKL IDTFSLIEHL QGLSQAVPRH TLREILDPSY QQKLMSGDQE QLVRFSIKPR RMGHITHSRR LLSRLRVRCS RMPPLSLWAG WVLDSSVFSK FIISLIFLNT FVLMVEIELM ESTNTALWPV KLALEVADWF ILLSFIVEIL LMWLASFSLF WKDAWNVFDF FVTLLSLLPE LVVLLGVPAH SVWLQLLRVC RVLRSLKLFA RFRQIKVILL ALVRALKSMT FLLMLLLIFF YIFAVTGVYF FREYSRSTIE GLEYNMFFSD LLNSLVTVFI LFTLDHWYAV LQDIWKVPES SRVFSSIYVI LWLLLGSIIF RNIIVAMMVT NFQNIRSELS EEMSHLEVQY KADMFKQQII QRRQHSESLR GTSLGKVSED IIETSDASDD DDDDDDDDDD DDDDDDDKSD ATESDNEESD SENSESENSE SEKIDPEKDY AKKSYPEKSH PEKSYPEKSH PEKSYPEKSH PKKSYDEQAE AEKVKEESKE KAYPVSHSIS SHGSTAADTA FLENLDWETL VHENLPGLMD MDQDDRIVWP RDSLFRYFEL LEKLQYNLEE RKKLQEFAVQ ALMSFEDK. It is sometimes possible for the material contained within the vial of "Cation channel sperm-associated protein 2 (Catsper2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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