Immunohistochemistry (IHC)
(Immunochemical staining of human EGLN1 in human kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human EGLN1 Polyclonal Antibody | anti-EGLN1 antibody
Anti-EGLN1 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
EGLN1; Polyclonal Antibody; Anti-EGLN1 Antibody; Rabbit Polyclonal; EGLN1 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-C1orf12 Antibody; Anti-ECYT3 Antibody; Anti-HIF-PH2 Antibody; Anti-HIFPH2 Antibody; Anti-HPH-2 Antibody; Anti-HPH2 Antibody; Anti-PHD2 Antibody; Anti-PNAS-118 Antibody; Anti-SM20 Antibody; Anti-ZMYND6 Antibody; anti-EGLN1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human EGLN1
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-EGLN1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:100-1:500
Immunogen
E Coli-derived Human EGLN1 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human EGLN1 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human EGLN1 in human kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human EGLN1 in human kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human EGLN1 in human liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human EGLN1 in human liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-EGLN1 antibody
EGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity. EGLN1 [encoding HIF (hypoxia-inducible factor)-prolyl hydroxylase 2] plays a pivotal role in the HIF pathway and has emerged as one of the most intriguing genes for physiology at HA (high altitude). As a cellular oxygen sensor, PHD2 modifies hypoxia-inducible factor-alpha (HIF-alpha) protein for proteasomal destruction under normoxic conditions. Besides, 2-oxoglutarate-(OG-) dependent dioxygenase activity of PHD2 is involved in the oxygen and iron regulation of iron-responsive element-binding protein 2 (IRP2) stability. The EGLN1 locus exhibits a signature of positive selection in Tibetan and Andean populations and is associated with hemoglobin concentration in Tibetans. EGLN1 appears to have a potential role in the functional adaptation to the hypobaric hypoxic environment.
References
Mishra A, et al. (2013) Egln1 variants influence expression and sao2 levels to associate with high-altitude pulmonary oedema and adaptation. Clin Sci (Lond) 124 (7): 479-489.Heinrich EC, et al. (2019) Genetic variants at the egln1 locus associated with high-altitude adaptation in tibetans are absent or found at low frequency in highland andeans. Ann Hum Genet 83 (3): 171-176.Chiang HL, et al. (2020) Genetic analysis of egln1 c127s variant in taiwanese parkinson's disease. Parkinsons Dis 2020 9582317.
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Product Notes
The EGLN1 (Catalog #AAA8110103) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-EGLN1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's EGLN1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:100-1:500. Researchers should empirically determine the suitability of the EGLN1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EGLN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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