Calsequestrin 2 (CASQ2) Recombinant Protein | CASQ2 recombinant protein

Recombinant Calsequestrin 2 (CASQ2)

Cat. Num. AAA2086931

• Gene Names: Casq2; Csq2; cCSQ; ESTM52; AA033488; AW146219
• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Calsequestrin 2 (CASQ2); Recombinant Calsequestrin 2 (CASQ2); PDIB2; Cardiac Muscle Calsequestrin; Calsequestrin; cardiac muscle isoform; CASQ2 recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 415

• Applicable Applications for CASQ2 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Fragment: Glu20~Lys320
• Tag: N-terminal His-tag
• Buffer Formulation: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Prokaryotic expression
• Organism Species: Mouse
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 4.6
• Subcellular Location: Sarcoplasmic Reticulum Lumen.
• Usage: Reconstitute in sterile ddH2O.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

Product Categories/Family for CASQ2 recombinant protein

Recombinant Protein

NCBI and Uniprot Product Information

• NCBI GI #: 157951700
• NCBI GeneID: 12373
• NCBI Accession #: NP_033944.2
• NCBI GenBank Nucleotide #: NM_009814.3
• UniProt Accession #: O09161; O88505; Q56A03
• Molecular Weight: 39.0kDa
• NCBI Official Full Name: calsequestrin-2
• NCBI Official Synonym Full Names: calsequestrin 2
• NCBI Official Symbol: Casq2
• NCBI Official Synonym Symbols: Csq2; cCSQ; ESTM52; AA033488; AW146219
• NCBI Protein Information: calsequestrin-2
• UniProt Protein Name: Calsequestrin-2
• Protein Family: Calsequestrin
• UniProt Gene Name: Casq2

Uniprot Description

calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 3|3 F2.2

Cellular Component: cytoplasm; intracellular; junctional membrane complex; sarcoplasmic reticulum; sarcoplasmic reticulum lumen; Z disc

Molecular Function: calcium ion binding; calcium-dependent protein binding; protein homodimerization activity; protein kinase C binding

Biological Process: cardiac muscle contraction; negative regulation of potassium ion transport; protein polymerization; regulation of heart rate; regulation of muscle contraction; sarcomere organization; sequestering of calcium ion