CASP8-associated protein 2 (Casp8ap2) Recombinant Protein | Casp8ap2 recombinant protein

Recombinant Mouse CASP8-associated protein 2 (Casp8ap2) , partial

Cat. Num. AAA1430831

• Gene Names: Casp8ap2; FLASH; D4Ertd659e
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: CASP8-associated protein 2 (Casp8ap2); Recombinant Mouse CASP8-associated protein 2 (Casp8ap2); partial; Casp8ap2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1685-1962. Partial,include NCOA2-binding Region
• Sequence: LNVDHLECSQTNLDQDAEITCSSLQPDTIDAFIDLTHDASSESKNEGSEPVLAVEGMGCQVICIDEDTNKEGKMGRANSPLESIVEETCIDLTSESPGSCEIKRHNLKSEPPSKLDCLELPETLGNGHKKRKNSPGVSHSSQKKQRKDIDLSSEKTQRLSPNSDRNGDAHRKQASKKREPAVNETSLSSEASPEVKGSTAVLAASPASLSAKNVIKKKGEIIVSWTRNDDREILLECQKRMPSLKTFTYLAVKLNKNPNQVSERFQQLKKLFEKSKCR

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 172072595
• NCBI GeneID: 26885
• NCBI Accession #: NP_001116450.1
• NCBI GenBank Nucleotide #: NM_001122978.2
• UniProt Accession #: Q9WUF3; Q9CSW2; B1AX74
• Molecular Weight: 219,091 Da
• NCBI Official Full Name: CASP8-associated protein 2
• NCBI Official Synonym Full Names: caspase 8 associated protein 2
• NCBI Official Symbol: Casp8ap2
• NCBI Official Synonym Symbols: FLASH; D4Ertd659e
• NCBI Protein Information: CASP8-associated protein 2
• UniProt Protein Name: CASP8-associated protein 2
• Protein Family: CASP8-associated protein
• UniProt Gene Name: Casp8ap2

Uniprot Description

Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (). Required for histone gene transcription and progression through S phase (). Required for histone gene transcription and S phase progression (). Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis.