Mouse calcium/calmodulin-dependent serine protein kinase (MAGUK family) ELISA Kit | CASK elisa kit
Mouse Peripheral plasma membrane protein CASK, CASK ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
CASK: a MAGUK family protein and a protein kinase of the CAMK group. Contains one protein kinase domain, one guanylate kinase domain, two L27 domains, one PDZ domain and one SH3 domain. Plays a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Lacks the canonical DFG motif required for Mg++ binding, but retains protein kinase activity even without binding Mg++. Six alternatively spliced human isoforms have been described.
Protein type: Adaptor/scaffold; Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; CASK family
Cellular Component: focal adhesion; protein complex; nuclear matrix; basolateral plasma membrane; dendrite; intercellular junction; cytosol; presynaptic membrane; nuclear lamina; membrane; cytoplasm; plasma membrane; nucleolus; basement membrane; synapse; nucleus
Molecular Function: protein C-terminus binding; nucleotide binding; PDZ domain binding; protein kinase activity; transferase activity; calmodulin binding; protein serine/threonine kinase activity; protein binding; neurexin binding; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; ATP binding
Biological Process: intracellular protein transport; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell-matrix adhesion; protein amino acid phosphorylation; phosphorylation
Research Articles on CASK
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Product Notes
The Mouse CASK cask (Catalog #AAA9328295) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328295 ELISA Kit recognizes Mouse CASK. It is sometimes possible for the material contained within the vial of "calcium/calmodulin-dependent serine protein kinase (MAGUK family), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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