SDS-PAGE
CADM3 / NECL1 / IGSF4B recombinant protein
Recombinant Rat CADM3 / NECL1 / IGSF4B Protein (His tag)
Gene Names
Cadm3; Igsf4b; Necl-1
Purity
> 90 % as determined by SDS-PAGE
Synonyms
CADM3 / NECL1 / IGSF4B; Recombinant Rat CADM3 / NECL1 / IGSF4B Protein (His tag); Igsf4b; Necl-1; CADM3 / NECL1 / IGSF4B recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.5
Sequence Length
396
Application Notes
The recombinant rat CADM3 comprises 317 amino acids and predicts a molecular mass of 35 kDa. The apparent molecular mass of the ratCADM3 is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Asn 23
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
SDS-PAGE
Related Product Information for CADM3 / NECL1 / IGSF4B recombinant protein
Background: Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion. These proteins are typically transmembrane receptors and are composed of three domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain that interacts either with other CAMs of the same kind (homophilic binding) or with other CAMs or the extracellular matrix (heterophilic binding). Cell adhesion molecule 3, also known as Immunoglobulin superfamily member 4B, CADM3, and NECL1, is a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca (2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons. Isoform 1 of CADM3 is expressed mainly in adult and fetal brain. Isoform 2 of CADM3 is highly expressed in adult brain and weakly expressed in placenta. In brain, Isoform 2 is highly expressed in cerebellum. CADM3 is involved in the cell-cell adhesion. It has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. The interaction with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation.
Description: A DNA sequence encoding the rat CADM3 (Q1WIM3) extracellular domain (Met 1-His 328) was expressed, fused with a polyhistidine tag at the C-terminus.
Description: A DNA sequence encoding the rat CADM3 (Q1WIM3) extracellular domain (Met 1-His 328) was expressed, fused with a polyhistidine tag at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42,906 Da
NCBI Official Full Name
cell adhesion molecule 3
NCBI Official Synonym Full Names
cell adhesion molecule 3
NCBI Official Symbol
Cadm3
NCBI Official Synonym Symbols
Igsf4b; Necl-1
NCBI Protein Information
cell adhesion molecule 3
UniProt Protein Name
Cell adhesion molecule 3
UniProt Gene Name
Cadm3
UniProt Synonym Gene Names
Igsf4b; Necl1; IgSF4B; NECL-1
Uniprot Description
CADM3: Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 13q24
Cellular Component: cell-cell adherens junction; integral to plasma membrane; intercellular junction
Molecular Function: cell adhesion molecule binding; protein homodimerization activity; receptor activity; receptor binding
Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion; protein localization
Research Articles on CADM3 / NECL1 / IGSF4B
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Product Notes
The CADM3 / NECL1 / IGSF4B cadm3 (Catalog #AAA2547416) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat CADM3 comprises 317 amino acids and predicts a molecular mass of 35 kDa. The apparent molecular mass of the ratCADM3 is approximately 35-40 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the CADM3 / NECL1 / IGSF4B cadm3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CADM3 / NECL1 / IGSF4B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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