Butyrophilin Subfamily 3 Member A1/BTN3A1 Biotinylated Recombinant Protein | BTN3A1 recombinant protein

Recombinant Human Butyrophilin Subfamily 3 Member A1/BTN3A1 (C-Fc-Avi) Biotinylated

Cat. Num. AAA2569186

• Gene Names: BTN3A1; BTF5; BT3.1; CD277; BTN3.1
• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: Butyrophilin Subfamily 3 Member A1/BTN3A1 Biotinylated; Recombinant Human Butyrophilin Subfamily 3 Member A1/BTN3A1 (C-Fc-Avi) Biotinylated; Butyrophilin subfamily 3 member A1; CD277; BTN3A1; BTF5; BTN3A1 recombinant protein

• Host: Human Cells
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Gln30-Gly254

• Species: Human
• Tag: C-Fc-Avi
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Biotinylated Recombinant Human Butyrophilin Subfamily 3 Member A1 is produced by our Mammalian expression system and the target gene encoding Gln30-Gly254 is expressed with a Fc, Avi tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for BTN3A1 recombinant protein

Butyrophilin Subfamily 3 Member A1 (BTN3A1/CD277) is a type I transmembrane glycoprotein member of the Ig superfamily. It is expressed on a wide variety of immune cells. Similar to BTN3A2 and BTN3A3, BTN3A1 is composed of an extracellular N-terminal IgV and a membraneproximal IgC domain followed by a transmembrane domain and a cytoplasmic tail. These Ig domains are also found in B7 family costimulatory molecules, suggesting structural and functional similarities between the two protein families. BTN3A1 acts as a critical protein for the activation of Vgamma9Vdelta2 T cells following detection of distressed cells. The anti-tumor responses of Vgamma9Vdelta2 T cells may be enhanced with agonistic anti-BTNA3 antibodies.

Product Categories/Family for BTN3A1 recombinant protein

immunology

NCBI and Uniprot Product Information

• NCBI GI #: 117949374
• NCBI GeneID: 11119
• UniProt Accession #: O00481; Q0P515; Q147X5; Q53F15; Q99420; Q9HCY1; A2A278; A8K2C8; B4DIQ1; B4DRM2; E9PGB4; E9PHG8
• Molecular Weight: 52,019 Da
• NCBI Official Full Name: Butyrophilin subfamily 3 member A1
• NCBI Official Synonym Full Names: butyrophilin subfamily 3 member A1
• NCBI Official Symbol: BTN3A1
• NCBI Official Synonym Symbols: BTF5; BT3.1; CD277; BTN3.1
• NCBI Protein Information: butyrophilin subfamily 3 member A1
• UniProt Protein Name: Butyrophilin subfamily 3 member A1
• Protein Family: Butyrophilin subfamily
• UniProt Gene Name: BTN3A1
• UniProt Synonym Gene Names: BTF5

NCBI Description

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

Uniprot Description

Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.