Butyrophilin Subfamily 2 Member A2/BTN2A2 Biotinylated Recombinant Protein | BTN2A2 recombinant protein

Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc-Avi) Biotinylated

Cat. Num. AAA2569180

• Gene Names: BTN2A2; BTF2; BT2.2; BTN2.2
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Butyrophilin Subfamily 2 Member A2/BTN2A2 Biotinylated; Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc-Avi) Biotinylated; Butyrophilin subfamily 2 member A2; BTN2A2; BTN2A2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Gln33-Val237

• Species: Human
• Tag: C-Fc-Avi
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Biotinylated Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc, Avi tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

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Related Product Information for BTN2A2 recombinant protein

Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naïve B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.

Product Categories/Family for BTN2A2 recombinant protein

Cell biology; Cancer; immunology

NCBI and Uniprot Product Information

• NCBI GI #: 308522746
• NCBI GeneID: 10385
• NCBI Accession #: NP_001184166.1
• NCBI GenBank Nucleotide #: NM_001197237.1
• UniProt Accession #: Q8WVV5; O00480; A6NM84; B4DE97; B4DQ01; E9PH07
• Molecular Weight: 35,493 Da
• NCBI Official Full Name: butyrophilin subfamily 2 member A2 isoform a
• NCBI Official Synonym Full Names: butyrophilin, subfamily 2, member A2
• NCBI Official Symbol: BTN2A2
• NCBI Official Synonym Symbols: BTF2; BT2.2; BTN2.2
• NCBI Protein Information: butyrophilin subfamily 2 member A2; butyrophilin 2
• UniProt Protein Name: Butyrophilin subfamily 2 member A2
• Protein Family: Butyrophilin subfamily
• UniProt Gene Name: BTN2A2
• UniProt Synonym Gene Names: BT2.2; BTF2
• UniProt Entry Name: BT2A2_HUMAN

NCBI Description

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]