Transcription factor BTF3 Recombinant Protein | BTF3 recombinant protein

Recombinant Human Transcription factor BTF3 protein

Cat. Num. AAA9421588

• Gene Names: BTF3; NACB; BTF3a; BTF3b; BETA-NAC
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Transcription factor BTF3; Recombinant Human Transcription factor BTF3 protein; Nascent polypeptide-associated complex subunit beta; NAC-betaRNA polymerase B transcription factor 3; BTF3 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Partial of the Full Length of 1-206aa, 48-206aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for BTF3 recombinant protein

When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they erge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.

NCBI and Uniprot Product Information

• NCBI GI #: 83641885
• NCBI GeneID: 689
• NCBI Accession #: NP_001032726.1
• NCBI GenBank Nucleotide #: NM_001037637.1
• UniProt Accession #: P20290; Q13893; Q76M56; A8K510
• Molecular Weight: 44.7kD
• NCBI Official Full Name: transcription factor BTF3 isoform A
• NCBI Official Synonym Full Names: basic transcription factor 3
• NCBI Official Symbol: BTF3
• NCBI Official Synonym Symbols: NACB; BTF3a; BTF3b; BETA-NAC
• NCBI Protein Information: transcription factor BTF3
• UniProt Protein Name: Transcription factor BTF3
• Protein Family: Transcription factor
• UniProt Gene Name: BTF3
• UniProt Synonym Gene Names: NACB; NAC-beta

NCBI Description

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Uniprot Description

BTF3: a general transcription factor. BTF3 can form a stable complex with RNA polymerase II. An interaction partner of protein kinase CK2. Required for the initiation of transcription. Expressed at high levels in glioblastoma multiforme. Overexpressed in the microsatellite instability (MIN) phenotypes in colorectal cancer. Up-regulated strongly in the mammary gland during pregnancy, suggesting an involvement in alveolar growth. Two alternatively spliced isoforms have been described.

Protein type: Transcription factor; Transcription initiation complex

Chromosomal Location of Human Ortholog: 5q13.2

Cellular Component: cytosol

Molecular Function: protein binding; RNA binding

Biological Process: transcription from RNA polymerase II promoter