Keratin K18 Native Protein | KRT18 native protein

Keratin K18 protein

Cat. Num. AAA536600

• Gene Names: KRT18; K18; CYK18
• Applications: User optimized
• Purity: > 95% pure
• Synonyms: Keratin K18; Keratin K18 protein; Keratin K 18; Cytokeratin 18 protein; Keratin 18 protein; Keratin K-18; Keratin K-18 protein; Keratin K 18 protein; KRT18 native protein

• Host: Bovine
• Purity/Purification: > 95% pure
• Form/Format: Supplied in lyophilized form with 30 mM Tris/HCI pH 8.0, 9 M urea, 2 mM DTT, 2 mM EDTA, 10 mM methylammonium chloride
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 430

• Applicable Applications for KRT18 native protein: User optimized
• Source Note: Bovine liver
• Protein Type: Native
• Biological Significance: Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
• Preparation and Storage: Store at 2-8 degree C in lyophilized form. Following reconstitution aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for KRT18 native protein

Purified native Bovine Keratin K18 Protein

Product Categories/Family for KRT18 native protein

Cell Biology; Native Protein

NCBI and Uniprot Product Information

• NCBI GI #: 40354195
• NCBI GeneID: 3875
• NCBI Accession #: NP_954657.1
• NCBI GenBank Nucleotide #: NM_199187.1
• UniProt Accession #: P05783; Q53G38; Q5U0N8; Q9BW26
• Molecular Weight: 45 kDa
• NCBI Official Full Name: keratin, type I cytoskeletal 18
• NCBI Official Synonym Full Names: keratin 18, type I
• NCBI Official Symbol: KRT18
• NCBI Official Synonym Symbols: K18; CYK18
• NCBI Protein Information: keratin, type I cytoskeletal 18
• UniProt Protein Name: Keratin, type I cytoskeletal 18
• Protein Family: Keratin
• UniProt Gene Name: KRT18
• UniProt Synonym Gene Names: CYK18; CK-18; K18
• UniProt Entry Name: K1C18_HUMAN

NCBI Description

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

K18: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 18 and its filament partner keratin 8 are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Defects are a cause of cryptogenic cirrhosis.

Protein type: Cytoskeletal; Nucleolus

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: perinuclear region of cytoplasm; cytoplasm; keratin filament; nucleolus; intermediate filament; microtubule organizing center

Molecular Function: protein binding; structural molecule activity

Biological Process: anatomical structure morphogenesis; viral reproduction; tumor necrosis factor-mediated signaling pathway; intermediate filament cytoskeleton organization and biogenesis; cell cycle; Golgi to plasma membrane CFTR protein transport; negative regulation of apoptosis

Disease: Cirrhosis, Familial