ZNRF1 blocking peptide

ZNRF1 Antibody (Center) Blocking Peptide

• Gene Names: ZNRF1; NIN283
• Synonyms: ZNRF1; ZNRF1 Antibody (Center) Blocking Peptide; E3 ubiquitin-protein ligase ZNRF1; 632-; Nerve injury-induced gene 283 protein; Zinc/RING finger protein 1; NIN283; ZNRF1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 227

• Cellular Location: Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Note: Associated with synaptic vesicle membranes in neurons
• Tissue Location: Expressed primarily in the nervous system, with expression higher in developing brain relative to adult Expressed at low levels in testis and thymus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ZNRF1 blocking peptide

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

NCBI and Uniprot Product Information

• NCBI GI #: 126253846
• NCBI GeneID: 84937
• UniProt Accession #: Q8ND25; Q9H083; D3DUJ9
• Molecular Weight: 29,777 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase ZNRF1
• NCBI Official Synonym Full Names: zinc and ring finger 1, E3 ubiquitin protein ligase
• NCBI Official Symbol: ZNRF1
• NCBI Official Synonym Symbols: NIN283
• NCBI Protein Information: E3 ubiquitin-protein ligase ZNRF1
• UniProt Protein Name: E3 ubiquitin-protein ligase ZNRF1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: ZNRF1
• UniProt Synonym Gene Names: NIN283
• UniProt Entry Name: ZNRF1_HUMAN

NCBI Description

This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]

Uniprot Description

ZNRF1: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 6.3.2.19; Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: cytosol; endosome; membrane

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination